Fetal and Postnatal Cortical Thyroid Hormone Levels and Bioindicators
thyroid hormones in serum and in brain were measured in fetal and neonatal rat cortex after graded levels of a thyroid hormone synthesis inhibitor were administered to pregnant rat dams. A number of gene targets were assessed to look for measures of thyroid hormone action in these same tissues.
This dataset is associated with the following publication:
OShaughnessy, K., C. Wood, R. Ford, P. Kosian, M. Hotchkiss, S. Degitz, and M. Gilbert. Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex- ToxSci. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163-179, (2018).
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1 resource available
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OShaughnessyetalScienceHub.xlsx
APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| bureauCode |
[ "020:00" ] |
| contactPoint |
{ "fn": "Mary Gilbert", "hasEmail": "mailto:gilbert.mary@epa.gov" } |
| description | thyroid hormones in serum and in brain were measured in fetal and neonatal rat cortex after graded levels of a thyroid hormone synthesis inhibitor were administered to pregnant rat dams. A number of gene targets were assessed to look for measures of thyroid hormone action in these same tissues. This dataset is associated with the following publication: OShaughnessy, K., C. Wood, R. Ford, P. Kosian, M. Hotchkiss, S. Degitz, and M. Gilbert. Thyroid hormone disruption in the fetal and neonatal rat: Predictive hormone measures and bioindicators of hormone action in the developing cortex- ToxSci. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163-179, (2018). |
| distribution |
[ { "title": "OShaughnessyetalScienceHub.xlsx", "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet", "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1420050/OShaughnessyetalScienceHub.xlsx" } ] |
| identifier | https://doi.org/10.23719/1420050 |
| keyword |
[ "brain developoment", "molecular markers", "thyroid" ] |
| license | https://pasteur.epa.gov/license/sciencehub-license.html |
| modified | 2018-02-09 |
| programCode |
[ "020:095" ] |
| publisher |
{ "name": "U.S. EPA Office of Research and Development (ORD)", "subOrganizationOf": { "name": "U.S. Environmental Protection Agency", "subOrganizationOf": { "name": "U.S. Government" } } } |
| references |
[ "https://doi.org/10.1093/toxsci/kfy190" ] |
| rights |
null
|
| title | Fetal and Postnatal Cortical Thyroid Hormone Levels and Bioindicators |
