This strategic R&D Framework was developed to improve medical, functional, and public health outcomes through R&D in the use of data and IT for advanced health IT applications and improved detection of existing health concerns and discovery of emerging issues. It is expected that this Framework will help the United States capitalize on the full potential of health IT to improve the efficiency and effectiveness of healthcare and lengthen and improve the quality of American lives. This Framework will also help Federal agencies work across silos and prioritize areas for transformation by investing in tools and technologies that open new areas of discovery and better coordination of R&D activities. It does not define specific research agendas for individual Federal agencies; instead, agencies will continue to pursue priorities consistent with their missions, capabilities, authorities, and budgets, while maximizing planning, collaboration, and coordination with one another through the HITRD IWG to avoid duplicative efforts.