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Fates of Nanoparticles in Simulated Gastric Fluid Studied using Single-Particle-Inductively Coupled Plasma-Mass Spectrometry

Metadata Updated: March 9, 2021

This study adds to the growing knowledge of the fates of ENPs under conditions that simulate the human stomach. The fates of different nanoparticles after exposure to a simulated human digestion system is highly relevant to understand the impact of ENPs overall as they become more integrated into daily life, potentially resulting in increased exposures. Various factors such as species, size, the concentration of ingested ENPs, and body temperature on the fates of nanoparticles in the human digestion system proved to be varied and complex. This research highlights the need for a better understanding of nanomaterials' properties in the digestive system under other physiologically relevant conditions. This work contributes to an improved understanding of the fates of ENPs in gastric fluid, which gives insights into the gastrointestinal uptake of these ENPs before they enter into the blood circulation and organ systems. It is especially crucial for nanoparticles not completely solubilized in the digestive system's physiological contact time because these ENPs will enter into the other body systems and potentially circulate through the body as particulates. Using this study framework, sequentially studying in other tissues, especially for those ENPs not dissolved in SGF, including Ag-NPs, Au-NPs, and CeO¬2–NPs, would be valuable to evaluate the potential risk of ENPs to human health. This dataset is not publicly accessible because: The research continued, additional papers could be published from this data set. It can be accessed through the following means: Data will be placed in EPA file server. Format: Data is on spreadsheet, which includes dissolution rate of engineered nanoparticles of different particle size in simulated gastric fluid.

This dataset is associated with the following publication: He, X., H. Zhang, H. Shi, W. Liu, and E. Sahle-Demessie. Fates of Au, Ag, ZnO, and CeO2 Nanoparticles in Simulated Gastric Fluid Studied using Single-Particle-Inductively Coupled Plasma-Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY. Elsevier Science Ltd, New York, NY, USA, 31(10): 2180-2190, (2020).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

No file downloads have been provided. The publisher may provide downloads in the future or they may be available from their other links.

References

https://doi.org/10.1021/jasms.0c00278

Dates

Metadata Created Date March 9, 2021
Metadata Updated Date March 9, 2021

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date March 9, 2021
Metadata Updated Date March 9, 2021
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1520892
Data Last Modified 2020-07-21
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Data Dictionary https://pasteur.epa.gov/uploads/10.23719/1520892/documents/Data%20Dictionary_FateEngineeredNanoparticlee.docx
Data Dictionary Type application/vnd.openxmlformats-officedocument.wordprocessingml.document
Harvest Object Id 87f04d10-7333-4d95-adce-cdf0c8913f5a
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1021/jasms.0c00278
Source Datajson Identifier True
Source Hash 41eb0f958b776aa4b58b686b1a0762c47239db51
Source Schema Version 1.1

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