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Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (“GenX”) in C57BL/6 mice

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:41 AM | Dataset Last Updated: October 13, 2016
Raw data file outputs of serum and urine measurements of GenX in dosed rodents. This dataset is associated with the following publication: Rushing, B., Q. Hu, J. Franklin, R. McMahen, S. Dagnino, C. Higgins, M. Strynar, and J. DeWitt. Evaluation of the Immunomodulatory Effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (“GenX”) in C57BL/6 Mice. ENVIRONMENTAL TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 156(1): 179-189, (2017).

Resources

11 resources available

  • 1-15-14 Dewitt U2M3O-hexane dosed rodent urine.xml

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  • 1-21-14 Dewitt high redo U2M3O-hexane dosed rodent urine.xml

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  • 4-24-13 Dewitt dosed U2M3O-hexane male mice.xml

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  • 4-29-13 redo Dewitt U2MO3-hex high dosed male mice.xml

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  • 5-29-13 redo Dewitt male mouse U2M3O-hexane 0 and 1 mg_kg.xml

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  • 5-30-13 Dewitt U2M30-hex dosed male mouse serum 10 and 100 mg_kg and high repeats.xml

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  • 5-31-13 Dewitt dosed male mice U2M3O-hexane high rerun samples.xml

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  • 9-6-13 Dweitt U2M3O hex 0 and 1 mg kg dosed.xml

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  • 9-6-13 Dweitt U2M3O hex 10 and 100 mg kg no IS dosed.xml

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  • 9-6-13 Dweitt U2M3O hex 10 repeat mg kg no IS dosed.xml

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  • Rushing et al_Raw Data.xls

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Mark Strynar",
  "hasEmail": "mailto:strynar.mark@epa.gov"
}
description Raw data file outputs of serum and urine measurements of GenX in dosed rodents. This dataset is associated with the following publication: Rushing, B., Q. Hu, J. Franklin, R. McMahen, S. Dagnino, C. Higgins, M. Strynar, and J. DeWitt. Evaluation of the Immunomodulatory Effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (“GenX”) in C57BL/6 Mice. ENVIRONMENTAL TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 156(1): 179-189, (2017).
distribution 
[
  {
    "title": "1-15-14 Dewitt U2M3O-hexane dosed rodent urine.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/1-15-14%20Dewitt%20U2M3O-hexane%20dosed%20rodent%20urine.xml"
  },
  {
    "title": "1-21-14 Dewitt high redo U2M3O-hexane dosed rodent urine.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/1-21-14%20Dewitt%20high%20redo%20U2M3O-hexane%20dosed%20rodent%20urine.xml"
  },
  {
    "title": "4-24-13 Dewitt dosed U2M3O-hexane male mice.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/4-24-13%20Dewitt%20dosed%20U2M3O-hexane%20male%20mice.xml"
  },
  {
    "title": "4-29-13 redo Dewitt U2MO3-hex high dosed male mice.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/4-29-13%20redo%20Dewitt%20U2MO3-hex%20high%20dosed%20male%20mice.xml"
  },
  {
    "title": "5-29-13 redo Dewitt male mouse U2M3O-hexane 0 and 1 mg_kg.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/5-29-13%20redo%20Dewitt%20male%20mouse%20U2M3O-hexane%200%20and%201%20mg_kg.xml"
  },
  {
    "title": "5-30-13 Dewitt U2M30-hex dosed male mouse serum 10 and 100 mg_kg and high repeats.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/5-30-13%20Dewitt%20U2M30-hex%20dosed%20male%20mouse%20serum%2010%20and%20100%20mg_kg%20and%20high%20repeats.xml"
  },
  {
    "title": "5-31-13 Dewitt dosed male mice U2M3O-hexane high rerun samples.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/5-31-13%20Dewitt%20dosed%20male%20mice%20U2M3O-hexane%20high%20rerun%20samples.xml"
  },
  {
    "title": "9-6-13 Dweitt U2M3O hex 0 and 1 mg kg dosed.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/9-6-13%20Dweitt%20U2M3O%20hex%200%20and%201%20mg%20kg%20dosed.xml"
  },
  {
    "title": "9-6-13 Dweitt U2M3O hex 10 and 100 mg kg no IS dosed.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/9-6-13%20Dweitt%20U2M3O%20hex%2010%20and%20100%20mg%20kg%20no%20IS%20dosed.xml"
  },
  {
    "title": "9-6-13 Dweitt U2M3O hex 10 repeat  mg kg no IS dosed.xml",
    "mediaType": "text/xml",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/9-6-13%20Dweitt%20U2M3O%20hex%2010%20repeat%20%20mg%20kg%20no%20IS%20dosed.xml"
  },
  {
    "title": "Rushing et al_Raw Data.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/433/Rushing%20et%20al_Raw%20Data.xls"
  }
]
identifier A-9gj6-433
keyword 
[
  "GenX",
  "immunotoxicity",
  "per and polyfluorinated",
  "serum",
  "urine"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2016-10-13
programCode 
[
  "020:095"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1093/toxsci/kfw251"
]
rights 
null
title Evaluation of the immunomodulatory effects of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (“GenX”) in C57BL/6 mice

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