The coastal region which includes areas within South Carolina and North Carolina was chosen as a focus area study (FAS) for the U.S. Geological Survey (USGS) National Water Census (NWC) in 2016. The objective of the NWC is to place technical information and tools in the hands of stake holders so that they can make informed decisions on water availability. The USGS South Atlantic Water Science Center, comprised of North Carolina, South Carolina, and Georgia, conducted a 3-year study of water use and availability, climate change, and population growth to provide information related to the competing societal and ecological water needs in the Southeastern Atlantic Coastal Basins of the Carolinas. The Coastal Carolinas study area includes lower parts of the Yadkin/Pee Dee/Waccamaw River, Cape Fear River, and New River Basins extending from Georgetown, South Carolina up through Jacksonville, North Carolina area. One task to meet this objective was compiling water withdrawal and return data and other water-use information from local, regional, and state-scale data sources. This information was used to develop water-use estimates that could be used in a surface-water model, a groundwater model, and an ecological flow model. The simulations produced by these models could then be used to make predictions about future water availability and needs in the Coastal Carolina study area. This data release presents surface-water and groundwater off-stream water-use estimates for selected water use categories; for areas bounded by HUC8 and state boundaries within the Coastal Carolinas study area; from years 2000, 2005, 2010, and 2015.