The EPA Dynamically Downscaled Ensemble (EDDE) Version 2 is a collection of physics-based projections of future conditions, as well as historical simulations, dynamically downscaled from global climate models within the Sixth Coupled Model Intercomparison Project (CMIP6) using the Weather Research and Forecasting (WRF) model. EDDE V2 contains simulations over the historical period 1985-2014 and projections of a future period 2025-2100 under multiple Shared Socioeconomic Pathways (SSPs) downscaled on a 12-km domain over the contiguous U.S.  EDDE datasets are subset from WRF's output and then prepared by EPA/ORD staff and by contract staff who worked under the technical guidance of EPA/ORD staff. Data are in Network Common Data Form (netCDF) version 4, which is used in atmospheric modeling. The EDDE data in netCDF are further written to adhere to principles of Climate and Forecasting System (CF) Compliance, as outlined at https://cfconventions.org. The files are self-describing with metadata included in the netCDF header.