As included in this EnviroAtlas dataset, the community level domestic water use is calculated using locally available water use data per capita in gallons of water per day (GPD), distributed dasymetrically, and summarized by census block group. Domestic water use, as defined in this case, is intended to represent residential indoor and outdoor water use (e.g., cooking, hygiene, landscaping, pools, etc.) for primary residences (i.e., excluding second homes and tourism rentals). Two reports were used with city- or water supply authority- level domestic water demand data, in addition to county level data. The 2013 Jefferson County Data Book provides detailed publicly, privately, and self supplied water use and population served for 2013 and covers the Jefferson County, MO portion of the EnviroAtlas study area. The 2019 Census of Missouri Public Water Systems provides detailed publicly supplied water use and population served for 2019 and covers all of Missouri. The 2010 USGS Estimated Use of Water in the United States in 2010 report covers the missing areas, including counties in Illinois within the study area. Data from these reports were weighted across publicly, privately, and self-supplied sources by population served, resulting in a single water use estimate between 25 and 427 GPD for each of the subregions in the study area. This dataset was produced by the US EPA to support research and online mapping activities related to EnviroAtlas. EnviroAtlas (https://www.epa.gov/enviroatlas) allows the user to interact with a web-based, easy-to-use, mapping application to view and analyze multiple ecosystem services for the contiguous United States. The dataset is available as downloadable data (https://edg.epa.gov/data/Public/ORD/EnviroAtlas) or as an EnviroAtlas map service. Additional descriptive information about each attribute in this dataset can be found in its associated EnviroAtlas Fact Sheet (https://www.epa.gov/enviroatlas/enviroatlas-fact-sheets).