Effects of FC10-diol on Reproductive Endocrinology and Function in the Fathead Minnow (Pimephales promelas)

This dataset contains data generated from a study evaluating the effects of 1H,1H,10H,10H-perfluorodecane-1,10-diol (FC10-diol), in a multi-endpoint reproduction assay with the fathead minnow designed specifically for endocrine-disrupting chemicals. Fish were exposed for 21 d to five water concentrations of FC10-diol ranging from 0.68 to 68 µg/L, as well as 17β-estradiol (15 ng/L) as a positive control. The FC10-diol produced a suite of responses in both males and female fish that were indicative of a classical estrogen-receptor (ER) agonist, including significant effects on reproduction. Responses in males included changes in expression of four hepatic genes controlled by ER, induction of plasma vitellogenin (VTG), decreased expression of male secondary sexual characteristics, histopathological changes in the testis and kidney, and mortality in the highest FC10-diol treatment group. Effects in females from the high treatment group included altered ovarian expression of genes involved in steroid synthesis, decreased plasma steroids, elevated plasma VTG, and histological changes in the ovary and kidney. This dataset is associated with the following publication: Ankley, G., K. Jensen, J. Cavallin, C. Baettig, S. Balgooyen, B. Blackwell, C. Blanksma, J. Collins, M. Ellman, J. Hoang, M. Kahl, K. Santana-Rodriguez, C. Schaupp, E. Stacy, and D. Villeneuve. Effects of a novel estrogenic perfluoroalkyl substance on reproductive endocrinology and function in the fathead minnow (Pimephales promelas). ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, USA, 44(3): 786-801, (2025).

[
  "020:00"
]

{
  "fn": "Kathleen Jensen",
  "hasEmail": "mailto:jensen.kathleen@epa.gov"
}

[
  {
    "title": "FC10-diol Reproduction Study_Science Hub.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531979/FC10-diol%20Reproduction%20Study_Science%20Hub.xlsx"
  }
]

[
  "PFAS",
  "endocrine",
  "fish",
  "toxicity"
]

[
  "020:000"
]

{
  "name": "U.S. Environmental Protection Agency",
  "subOrganizationOf": {
    "name": "U.S. Government"
  }
}

[
  "https://doi.org/10.1093/etojnl/vgaf006"
]

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