Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays

Metadata Updated: November 12, 2020

This manuscript tests the hypothesis of dose additivity of an environmental mixture of pyrethriod insecticides at the level of network function, in vitro. The results demonstrate that permethrin, deltamethrin, esfenvalerate, cypermethrin and beta-cyfluthrin all change the activity of networks as measured by microelectrode arrays, and that the effects of an environmental-relevant mixture of these 5 compounds can be predicted based on a dose-additivity model. These results are consistent with results from in vivo experiments that examined motor activity. This study supports the Office of Pesticides decision to regulate mixtures of pyrethroids based on dose additivity.

This dataset is associated with the following publication: Johnstone , A., J. Strickland, K. Crofton , C. Gennings, and T. Shafer. Effects of an Environmentally-relevant Mixture of Pyrethroid Insecticides on Spontaneous Activity in Primary Cortical Networks on Microelectrode Arrays. NEUROTOXICOLOGY. Elsevier B.V., Amsterdam, NETHERLANDS, 60(16): 234-239, (2017).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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References

https://doi.org/10.1016/j.neuro.2016.05.005

Dates

Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Unique Identifier Unknown
Maintainer
Identifier https://doi.org/10.23719/1390091
Data Last Modified 2015-09-09
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id f037dab5-3cef-4f3e-9729-7f0a6f224d72
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Program Code 020:000
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1016/j.neuro.2016.05.005
Source Datajson Identifier True
Source Hash 1620feeb875c0d91af1f61da187e28841e4f49b6
Source Schema Version 1.1

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