The data in this data release are comprised of one geospatial vector dataset and three tabular datasets related to the HayWired earthquake scenario, a magnitude 7.0 earthquake hypothesized to occur on April 18, 2018, with an epicenter in the city of Oakland, CA. The geospatial vector data are a representation of identified economic subareas for use in selected analyses related to selected counties in and around the San Francisco Bay region in California. Census tracts in seven economic subareas were identified, as was whether a tract potentially has a high concentration of building stock extensively or completely damaged by (1) earthquake hazards (ground shaking, landslide, liquefaction) and (2) all hazards (ground shaking, landslide, liquefaction, and fire following earthquake) resulting from the HayWired earthquake scenario mainshock. The tabular data are (1) counts of employed residents (total and by industry grouping) in identified economic subareas within four counties (Alameda, Contra Costa, Marin, Solano) or (2) employed resident/worker commute flow counts (total and by general industry sector) for employees who work or reside in areas of concentrated damage in economic subareas within four counties (Alameda, Contra Costa, Marin, Solano) in the San Francisco Bay region in California. Basic employed resident counts are presented at the census tract level with the associated economic subarea and area of concentrated damage designation included as ancillary information. Employed resident/worker commute flows are presented as aggregations based on: seven economic subareas in Alameda, Contra Costa, Marin, and Solano Counties (distinguished by whether or not an area is considered an area of concentrated damage as a result of damage from ground shaking, landslide, liquefaction, and fire); the remaining counties touching San Francisco Bay; and three regions from beyond the nine-county San Francisco Bay region. These summary data are intended for use in selected analyses related to the regional impact resulting from the HayWired earthquake scenario mainshock. The vector .SHP dataset was developed and intended for use in GIS applications such as ESRI's ArcGIS software suite. The tab-delimited .TXT datasets were developed and intended for use in GIS applications (such as ESRI's ArcGIS software suite) and (or) standalone spreadsheet or database applications (such as Microsoft Excel or Access). These data support the following publication: Wein, A.M., Belzer, D., Kroll, C., Au, C., Jones, J.L., Johnson, L.A., Olsen, A., and Peters, J., 2020, Spatial analysis of industries, employment, and commute flows in areas of concentrated damage from the HayWired earthquake scenario, chap. V5 of Detweiler, S.T., and Wein, A.M., eds., The HayWired earthquake scenario--Societal consequences: U.S. Geological Survey Scientific Investigations Report 2017-5013, https://doi.org/10.3133/sir20175013.