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E331 Behavior TP HF RW O3 SHC2.63

Metadata Updated: November 12, 2020

Human and animal studies indicate that maternal obesity can negatively impact aspects of metabolism and neurodevelopment in the offspring. Not known, however, is whether maternal exercise can alter these adverse outcomes. In this study, Long-Evans female rats were provided a high fat (60%; HFD) or control diet (CD) 44 days before mating and throughout gestation and lactation. Running wheels were available to half of each diet group during the gestational period only: CD diet with (CDRW) or without (sedentary; CDSED) exercise, and HFD with (HFRW) or without (HFSED) exercise. The offspring in this study were put on control diet after weaning and examined using a number of behavioral evaluations up to 4 months of age. Offspring of CDRW dams weighed less than offspring from CDSED dams, as well as from HFD dams. After weaning, the lower weight in CDRW offspring persisted in male, but not female, rats. Male (females not tested) offspring from HFSED dams performed worse than other groups in a Morris water maze during initial spatial training as well as reversal learning; memory was not impacted. Female, but not male, offspring from the HFSED dams showed less preference for chocolate milk during a 2-bottle choice test. No differences were seen in tests of novel object recognition, social approach, or locomotor activity. Thus, maternal diet and exercise produced differential effects on growth and selective behaviors in the offspring, and the data demonstrate a positive impact of maternal exercise on the offspring in that it ameliorated some deleterious behavioral effects of a maternal high fat diet.

This dataset is associated with the following publication: Moser, V., K. Mcdaniel, E. Wooland, P. Phillips, J. Franklin, and C. Gordon. IMPACTS OF MATERNAL DIET AND EXERCISE ON OFFSPRING BEHAVIOR AND GROWTH. NEUROTOXICOLOGY AND TERATOLOGY. Elsevier Science Ltd, New York, NY, USA, 46-50, (2017).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Identifier A-jdg3-531
Data Last Modified 2017-03-24
Public Access Level public
Bureau Code 020:00
Schema Version
Harvest Object Id ddf93165-99ad-410e-b36f-773b62ca57e4
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:000
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash 24240acf980efd0b5c877968aeff4b977ecc33b7
Source Schema Version 1.1

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