These datasets provide the measurements and analytical data used to describe the evolution of Neogene faulting near Blythe, California. The data include structural measurements and results from Ar-Ar and U-Pb geochronology that address the research questions of the associated publication. Structural measurement datasets provide fault surface kinematic measurements and tabulations of structural data used in the manuscript stereoplots. Argon datasets include analytical data from Ar-Ar geochronology. U-Pb datasets include analytical data from calcite samples synkinematic with fault movement. Shear estimate datasets include estimations of fault slip magnitude in the Blythe region. These datasets are associated with a manuscript accepted for publication: Mavor, S.P., Bennett, S.E.K., Crow, R.S., Singleton, J.S., Langenheim, V., Stockli, D., Stelten, M., Brickey, T.A., Sr., Umhoefer, P.J., and Beard, L.S., 2023, Evolution of Miocene normal and dextral faulting in the lower Colorado River region near Blythe, California, USA: Geosphere, v. 19, https://doi.org/10.1130/GES02608.1.