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Differential expressed mRNA and microRNA from expression profiling by RNA and small RNA sequencing

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: April 21, 2026 at 08:04 PM | Dataset Last Updated: April 01, 2021
data was from HepG2 cells treated with nano-silver particles using silver nitrate as negative controls. Differentially expressed messenger RNA and microRNA were obtained by RNA sequencing and data analysis. Differentially expressed RNA and microRNA lists were than uploaded to Ingenuity Pathway Analysis to find the pathways altered by the differentially expressed genes. This dataset is associated with the following publication: Thai, S., C. Jones, B. Robinette, H. Ren, B. Vallanat, A. Fisher, and K. Kitchin. Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2). Journal of Nanoscience and Nanotechnology. American Scientific Publishers, VALENCIA, CA, USA, 21(11): 5414-5428, (2021).

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  • AgNO3 miR lists.csv

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  • AgS miRNA lists.xlsx

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  • DEG-0.05-result_AgNO3_0_25.xlsx

    APPLICATION/VND.OPENXMLFORMATS-OFFICEDOCUMENT.SPREADSHEETML.SHEET
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  • DEG-0.05-result_AgNO3_0_5.xlsx

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  • DEG-0.05-result_AgNO3_1.xlsx

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  • DEG-0.05-result_AgNO3_1_8.xlsx

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  • DEG-0.05-result_AgS_10.xlsx

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  • DEG-0.05-result_AgS_20.xlsx

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  • DEG-0.05-result_AgS_40.xlsx

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  • DEG-0.05-result_AgS_5.xlsx

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Sheau-Fung Thai",
  "hasEmail": "mailto:thai.sheau-fung@epa.gov"
}
description data was from HepG2 cells treated with nano-silver particles using silver nitrate as negative controls. Differentially expressed messenger RNA and microRNA were obtained by RNA sequencing and data analysis. Differentially expressed RNA and microRNA lists were than uploaded to Ingenuity Pathway Analysis to find the pathways altered by the differentially expressed genes. This dataset is associated with the following publication: Thai, S., C. Jones, B. Robinette, H. Ren, B. Vallanat, A. Fisher, and K. Kitchin. Effects of Silver Nanoparticles and Silver Nitrate on mRNA and microRNA Expression in Human Hepatocellular Carcinoma Cells (HepG2). Journal of Nanoscience and Nanotechnology. American Scientific Publishers, VALENCIA, CA, USA, 21(11): 5414-5428, (2021).
distribution 
[
  {
    "title": "AgNO3 miR lists.csv",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/AgNO3%20miR%20lists.csv"
  },
  {
    "title": "AgS miRNA lists.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/AgS%20miRNA%20lists.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgNO3_0_25.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgNO3_0_25.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgNO3_0_5.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgNO3_0_5.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgNO3_1.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgNO3_1.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgNO3_1_8.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgNO3_1_8.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgS_10.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgS_10.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgS_20.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgS_20.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgS_40.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgS_40.xlsx"
  },
  {
    "title": "DEG-0.05-result_AgS_5.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1520580/DEG-0.05-result_AgS_5.xlsx"
  }
]
identifier https://doi.org/10.23719/1520580
keyword 
[
  "Target Filter Analysis",
  "microRNA expression",
  "nano silver",
  "signaling pathways",
  "silver nitrate",
  "transcriptomics"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2021-04-01
programCode 
[
  "020:095"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1166/jnn.2021.19481"
]
rights 
null
title Differential expressed mRNA and microRNA from expression profiling by RNA and small RNA sequencing

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