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Developmental toxicity of disinfection byproducts in F344 rats: effects on pregnancy maintenance and eye development

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:51 AM | Dataset Last Updated: November 20, 2024
Developmental toxicity of disinfection byproducts in F344 rats: effects on pregnancy maintenance and eye development. Data files for the experiments reported in the published journal article. Files include data for maternal body weights, gestation length, pup weights, number of implantation sites, and number of pups and litters affected with eye malformations. This dataset is associated with the following publication: Narotsky, M., L. Fuentes, O. Ola, T. Willoughby, and K. Lucas. Developmental Toxicity of Disinfection Byproducts in F344 Rats: Effects on Pregnancy Maintenance and Eye Development. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, USA, 117(1): e2427, (2025).

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13 resources available

  • BDCM&Bromoform1992.xlsx

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  • CDBM.xlsx

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  • Chloroform.xlsx

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  • DBA.xlsx

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  • DBNM.xlsx

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  • DIA.xlsx

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  • IAN.xlsx

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  • Iodoform.xlsx

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  • MBA.xlsx

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  • MBNM-DW.xlsx

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  • MCA.xlsx

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  • TCA-DW.xlsx

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  • TCA-gavage.xlsx

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Michael Narotsky",
  "hasEmail": "mailto:narotsky.michael@epa.gov"
}
description Developmental toxicity of disinfection byproducts in F344 rats: effects on pregnancy maintenance and eye development. Data files for the experiments reported in the published journal article. Files include data for maternal body weights, gestation length, pup weights, number of implantation sites, and number of pups and litters affected with eye malformations. This dataset is associated with the following publication: Narotsky, M., L. Fuentes, O. Ola, T. Willoughby, and K. Lucas. Developmental Toxicity of Disinfection Byproducts in F344 Rats: Effects on Pregnancy Maintenance and Eye Development. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, USA, 117(1): e2427, (2025).
distribution 
[
  {
    "title": "BDCM&Bromoform1992.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/BDCM%26Bromoform1992.xlsx"
  },
  {
    "title": "CDBM.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/CDBM.xlsx"
  },
  {
    "title": "Chloroform.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/Chloroform.xlsx"
  },
  {
    "title": "DBA.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/DBA.xlsx"
  },
  {
    "title": "DBNM.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/DBNM.xlsx"
  },
  {
    "title": "DIA.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/DIA.xlsx"
  },
  {
    "title": "IAN.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/IAN.xlsx"
  },
  {
    "title": "Iodoform.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/Iodoform.xlsx"
  },
  {
    "title": "MBA.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/MBA.xlsx"
  },
  {
    "title": "MBNM-DW.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/MBNM-DW.xlsx"
  },
  {
    "title": "MCA.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/MCA.xlsx"
  },
  {
    "title": "TCA-DW.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/TCA-DW.xlsx"
  },
  {
    "title": "TCA-gavage.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1531874/TCA-gavage.xlsx"
  }
]
identifier https://doi.org/10.23719/1531874
keyword 
[
  "Developmental Toxicity",
  "Disinfection Byproducts (DBPs)",
  "Eye malformation",
  "Haloacetic Acids",
  "Halonitromethanes",
  "Pregnancy loss",
  "anophthalmia",
  "trihalomethanes"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2024-11-20
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.1002/bdr2.2427"
]
rights 
null
title Developmental toxicity of disinfection byproducts in F344 rats: effects on pregnancy maintenance and eye development

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