A drinking water method for seven pesticides and pesticide degradates was developed that addresses the occurrence monitoring needs of the U.S. Environmental Protection Agency (EPA) for a future Unregulated Contaminant Monitoring Regulation (UCMR). The method employs on-line solid phase extraction-liquid chromatography/tandem mass spectrometry (SPE-LC/MS/MS). On-line SPE-LC/MS/MS has the potential to offer cost-effective, faster, more sensitive, and more rugged methods than the traditional off-line SPE approach due to complete automation of the SPE process, as well as seamless integration with the LC/MS/MS system. Multi-laboratory data are presented that demonstrate method ruggedness and transferability. The final method meets all of the EPA’s UCMR survey requirements for sample collection and storage, precision, accuracy, and sensitivity.

This dataset is associated with the following publication: Shoemaker , J. Development and Multi-laboratory Verification of US EPA Method 543 for the Analysis of Drinking Water Contaminants by Online Solid Phase Extraction-LC–MS-MS. Journal of Chromatographic Science. Preston Publications Incorporated, Niles, IL, USA, 54(9): 1532-1539, (2016).