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Deiodinase 1 Screening of ToxCast Phase 1 Chemical Library

Metadata Updated: November 12, 2020

This excel spreadsheet contains the resultant data for over from inhibition assays with human Deiodinase 1 screened against the ToxCast Phase 1 chemical library and a few additional chemicals. Over 1800 chemicals were tested in total. It contains the list of chemicals tested and the median, minimum, and maximum inhibition for each chemical screened at 200 µM. Chemicals that gave greater than 50% inhibition were screened in concentration response mode, and the median, min, max inhibition at each concentration for those chemicals are included. Propylthiouracil was used in each plate as a positive control and the concentration-response data for those curves are also included.

This dataset is associated with the following publication: Hornung, M., J. Korte, J. Olker, J. Denny, C. Knutsen, P. Hartig, M. Cardon, and S. Degitz. Screening the ToxCast Phase 1 chemical library for inhibition of deiodinase type 1 activity. TOXICOLOGICAL SCIENCES. Society of Toxicology, 162(2): 570-581, (2018).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

References

https://doi.org/10.1093/toxsci/kfx279

Dates

Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1376911
Data Last Modified 2017-08-16
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id d03d1abd-c505-4dce-b3fd-839c320110ce
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license.html
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1093/toxsci/kfx279
Source Datajson Identifier True
Source Hash ad3104e193d3f72b5cb69b265c189e7bd11052e1
Source Schema Version 1.1

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