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Datasets for "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes" manuscript

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: September 10, 2026 at 06:59 PM | Dataset Last Updated: May 26, 2023
These data are associated with the figures and tables presented in the manuscript "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes". Each spreadsheet contains the data for each Figure and metadata describes each column and/or row of data. For access to the smallRNA-seq files, please follow link provided and supply the reviewer key code "mjsnewymzlollmz".

Resources

14 resources available

  • https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgeo%2Fquery%2Facc.cgi%3Facc%3DGSE224206&data=05%7C01%7Cchorley.brian%40epa.gov%7C27ee61ce8e304700d81408db5e0f7b56%7C88b378b367484867acf976aacbeca6a7%7C0%7C0%7C638207192805056945%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=RmAfdJYzv5P0V3CIJxPVJezpARTMiQr8JalXavIcPmQ%3D&reserved=0

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  • Fig. 1ABC filtered mRNA.xlsx

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  • Fig. 2ABC filtered miRNA.xlsx

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  • Fig. 3A 8mg canonical pathways.xls

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  • Fig. 3B carcin dose target analysis.xls

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  • Fig. 4A 8mg Diseases and Bio Functions.xls

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  • Fig. 4B yellow green target Diseases and Bio Functions.xls

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  • Fig. 5A 8mg upstream regulators.xls

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  • Fig. 5B molecules for graphical summary_REMOVE.xls

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  • Fig. 6. Combined Analyses_filtered.xlsx

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  • Fig. 7. Combined Analyses_filtered.xlsx

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  • Fig. 8 normalized blood miRs_oneway_0.05_NOMTC_foldfilter1.3_BMD_filtered.xlsx

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  • Suppl Fig. 1.xlsx

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  • Suppl Fig. 3.Cell culture norm to 221 & 324_NormalizedData.csv

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Complete Metadata
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Brian Chorley",
  "hasEmail": "mailto:chorley.brian@epa.gov"
}
description These data are associated with the figures and tables presented in the manuscript "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes". Each spreadsheet contains the data for each Figure and metadata describes each column and/or row of data. For access to the smallRNA-seq files, please follow link provided and supply the reviewer key code "mjsnewymzlollmz".
distribution 
[
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    "title": "https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgeo%2Fquery%2Facc.cgi%3Facc%3DGSE224206&data=05%7C01%7Cchorley.brian%40epa.gov%7C27ee61ce8e304700d81408db5e0f7b56%7C88b378b367484867acf976aacbeca6a7%7C0%7C0%7C638207192805056945%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=RmAfdJYzv5P0V3CIJxPVJezpARTMiQr8JalXavIcPmQ%3D&reserved=0",
    "accessURL": "https://gcc02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgeo%2Fquery%2Facc.cgi%3Facc%3DGSE224206&data=05%7C01%7Cchorley.brian%40epa.gov%7C27ee61ce8e304700d81408db5e0f7b56%7C88b378b367484867acf976aacbeca6a7%7C0%7C0%7C638207192805056945%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=RmAfdJYzv5P0V3CIJxPVJezpARTMiQr8JalXavIcPmQ%3D&reserved=0"
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    "title": "Fig. 1ABC filtered mRNA.xlsx",
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    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%201ABC%20filtered%20mRNA.xlsx"
  },
  {
    "title": "Fig. 2ABC filtered miRNA.xlsx",
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    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%202ABC%20filtered%20miRNA.xlsx"
  },
  {
    "title": "Fig. 3A 8mg canonical pathways.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%203A%208mg%20canonical%20pathways.xls"
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  {
    "title": "Fig. 3B carcin dose target analysis.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%203B%20carcin%20dose%20target%20analysis.xls"
  },
  {
    "title": "Fig. 4A 8mg Diseases and Bio Functions.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%204A%208mg%20Diseases%20and%20Bio%20Functions.xls"
  },
  {
    "title": "Fig. 4B yellow green target Diseases and Bio Functions.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%204B%20yellow%20green%20target%20Diseases%20and%20Bio%20Functions.xls"
  },
  {
    "title": "Fig. 5A 8mg upstream regulators.xls",
    "mediaType": "application/vnd.ms-excel",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%205A%208mg%20upstream%20regulators.xls"
  },
  {
    "title": "Fig. 5B molecules for graphical summary_REMOVE.xls",
    "mediaType": "application/x-ole-storage",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%205B%20molecules%20for%20graphical%20summary_REMOVE.xls"
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  {
    "title": "Fig. 6. Combined Analyses_filtered.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%206.%20Combined%20Analyses_filtered.xlsx"
  },
  {
    "title": "Fig. 7. Combined Analyses_filtered.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%207.%20Combined%20Analyses_filtered.xlsx"
  },
  {
    "title": "Fig. 8 normalized blood miRs_oneway_0.05_NOMTC_foldfilter1.3_BMD_filtered.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Fig.%208%20normalized%20blood%20miRs_oneway_0.05_NOMTC_foldfilter1.3_BMD_filtered.xlsx"
  },
  {
    "title": "Suppl Fig. 1.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Suppl%20Fig.%201.xlsx"
  },
  {
    "title": "Suppl Fig. 3.Cell culture norm to 221 & 324_NormalizedData.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529104/Suppl%20Fig.%203.Cell%20culture%20norm%20to%20221%20%26%20324_NormalizedData.csv"
  }
]
identifier https://doi.org/10.23719/1529104
keyword 
[
  "biomarkers",
  "liver",
  "microrna",
  "novel approach methodologies"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2023-05-26
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
null
rights 
null
title Datasets for "Early microRNA responses in rodent liver mediated by furan exposure establish dose thresholds for later adverse outcomes" manuscript

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