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Dataset for "Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid'

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: April 21, 2026 at 08:05 PM | Dataset Last Updated: September 08, 2023
These spreadsheets contain the underlying data, calculations, and R code for the figures of the manuscript "Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid". The first tab of every spreadsheet contains descriptions of the data (metadata). For clarifying questions regarding the data, please contact Dr. Brian Chorley (EPA-ORD) at chorley.brian@epa.gov. If you require a review token for the sequencing datasets located in the GEO links (RNAseq and RRBS), please contact Dr. Chorley. This dataset is associated with the following publication: Carswell, G., J. Chamberlin, B. Bennett, P. Bushel, and B. Chorley. Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid. Frontiers in Oncology. Frontiers, Lausanne, SWITZERLAND, 14: 1389634, (2024).

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  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242661

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  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242664

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  • https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242665

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  • Figure 3A_data.xlsx

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  • Figure 3B_data.xlsx

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  • Figure 4_data.xlsx

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  • Figure 6_data.xlsx

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  • Figure 8_data.xlsx

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  • Figures 2_5_7_9A_B_data.xlsx

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  • Figures 5C_7C_9C_data.xlsx

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
                                            [
  "020:00"
]
contactPoint 
                                            {
  "fn": "Brian Chorley",
  "hasEmail": "mailto:chorley.brian@epa.gov"
}
description These spreadsheets contain the underlying data, calculations, and R code for the figures of the manuscript "Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid". The first tab of every spreadsheet contains descriptions of the data (metadata). For clarifying questions regarding the data, please contact Dr. Brian Chorley (EPA-ORD) at chorley.brian@epa.gov. If you require a review token for the sequencing datasets located in the GEO links (RNAseq and RRBS), please contact Dr. Chorley. This dataset is associated with the following publication: Carswell, G., J. Chamberlin, B. Bennett, P. Bushel, and B. Chorley. Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid. Frontiers in Oncology. Frontiers, Lausanne, SWITZERLAND, 14: 1389634, (2024).
distribution 
                                            [
  {
    "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242661",
    "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242661"
  },
  {
    "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242664",
    "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242664"
  },
  {
    "title": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242665",
    "accessURL": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242665"
  },
  {
    "title": "Figure 3A_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figure%203A_data.xlsx"
  },
  {
    "title": "Figure 3B_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figure%203B_data.xlsx"
  },
  {
    "title": "Figure 4_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figure%204_data.xlsx"
  },
  {
    "title": "Figure 6_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figure%206_data.xlsx"
  },
  {
    "title": "Figure 8_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figure%208_data.xlsx"
  },
  {
    "title": "Figures 2_5_7_9A_B_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figures%202_5_7_9A_B_data.xlsx"
  },
  {
    "title": "Figures 5C_7C_9C_data.xlsx",
    "mediaType": "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1529544/Figures%205C_7C_9C_data.xlsx"
  }
]
identifier https://doi.org/10.23719/1529544
keyword 
                                            [
  "DNA methylation",
  "archival samples",
  "dichloroacetic acid",
  "liver cancer",
  "transcriptomics"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2023-09-08
programCode 
                                            [
  "020:000"
]
publisher 
                                            {
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
                                            [
  "https://doi.org/10.3389/fonc.2024.1389634",
  "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099211"
]
rights 
                                            null
title Dataset for "Persistent gene expression and DNA methylation alterations linked to carcinogenic effects of dichloroacetic acid'

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