This data release contains site information and potential explanatory factor data for 1,899 groundwater sites. These sites were used to assess groundwater quality in aquifers used for domestic and public drinking water supply in the southeastern San Joaquin Valley. The southeastern San Joaquin Valley (SESJV) study unit consists of five study areas whose boundaries are defined by the eponymous California Department of Water Resources groundwater subbasins of the San Joaquin Valley groundwater basin: Madera-Chowchilla, Kings, Kaweah, Tule, and Tulare Lake. The sites consist of 198 wells representing the domestic-supply aquifer and 1,701 wells representing the public-supply aquifer. The domestic-supply aquifer wells were sampled in 2013-2015 by the USGS for either the California Groundwater Ambient Monitoring and Assessment Program Priority Basin Project (GAMA-PBP) or the USGS National Water Quality Assessment project (NAWQA). The public-supply aquifer wells were either sampled by the USGS for the GAMA-PBP in 2005-2018 or have water-quality data in the California State Water Resources Control Board Division of Drinking Water (SWRCB-DDW) public database. The data types in this data release include site identification and location, well construction and lithology data, land use characteristics, groundwater age and oxidation-reduction classifications and aridity indices. Not all sites have data for all fields. Water-quality data for the sites are available from U.S. Geological Survey (2023), and California State Water Resources Control Board Division of Drinking Water (2023). The study design and the assessment results are presented in Burow and others (2024).