Representative dairy farms in major dairy regions of the United States were modeled using the Integrated Farm System Model to quantify potential reductions in greenhouse gas emissions using various mitigation strategies. Important data and information describing these 14 farms are documented in this table. These data include the farm location, number of cows and heifers maintained, milk produced, feeds and nutrient contents fed, crop areas, crop yields, fertilizer and lime application rates, irrigation water applied, milking and housing facilities, manure collection, storage and application methods used, and soil characteristics. Simulated output information for feed consumption, nutrient losses, fossil energy use, water use, and greenhouse gas emissions are listed for each farm. These data are published as supplementary information for the article “Strategies for mitigating greenhouse gas emissions from US dairy farms toward a net zero goal” published in the Journal of Dairy Science.