Data based on a total of 179 sorghum accessions from Ethiopia, Gambia, and Senegal maintained by the USDA-ARS, Plant Genetic Resources Conservation Unit, Griffin, Georgia, USA, and planted in replicated plots in Isabela, Puerto Rico. Data for anthracnose, grain mold and rust infections with various agronomic traits such as anthracnose, grain mold, rust, seed weight, percent germination rate, and grain yield, seed weight, panicle height, panicle length, and flowering time were collected in 2017 and 2018 by L. K. Prom, H. Cuevas, E. Ahn, T. S. Isakeit, and C. W. Magill. The disease rating was based on previously published scale of 1 to 5. Seed weight in grams was based on the weight of 100 randomly selected seeds from each replication. Percent germination based on the number of seeds that germinated out of 100 seeds placed on germination paper. At maturity, plant height was measured from the soil to the top of the plant in centimeters, and panicle length was measured from the first branch with racemes to the top of the panicle. Grain yield in grams was based on three harvested panicles per accession, and each panicle was threshed and weighed in grams. The flowering date was based on Julian days.