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Data for Haselman et al 2016 Development of the LAGDA: effects of tOP or TB in Xenopus laevis from embryo to juvenile

Metadata Updated: November 12, 2020

These data are from two studies conducted to evaluate the performance of the draft Larval Amphibian Growth and Development Assay for incorporation into the U.S. EPA's Endocrine Disruptor Screening Program Tier II testing battery. 4-tert-octylphenol was chosen as an environmental estrogenic compound and 17-beta-trenbolone was chosen as an environmental androgenic compound. Although the effects of these model environmental endocrine disruptors are not novel, these chemicals were used essentially as positive controls to represent each of the potential modes of toxicity that could be encountered by future unknown compounds ordered to be run through the LAGDA in support of risk assessment. Endpoints evaluated were larval growth and metamorphic development, blood thyroid hormone, thyroid histopathology, juvenile growth, juvenile histopathology of the liver, gonads, kidneys and reproductive ducts.

This dataset is associated with the following publication: Haselman , J., P. Kosian , J. Korte , A. Olmstead, T. Iguchi, R. Johnson , and S. Degitz. Development of the larval amphibian growth and development assay: Effects of chronic 4-tert-octylphenol or 17ß-trenbolone exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 36(12): 1639-1650, (2016).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2016-02-25
Public Access Level public
Bureau Code 020:00
Schema Version
Harvest Object Id 478bc6e5-f48c-47d8-8001-f373fdd18daf
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash 079d61029f71cb937f5cb113bd0faf0e10ce4e5c
Source Schema Version 1.1

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