These data are from two studies conducted to evaluate the performance of the draft Larval Amphibian Growth and Development Assay for incorporation into the U.S. EPA's Endocrine Disruptor Screening Program Tier II testing battery. 4-tert-octylphenol was chosen as an environmental estrogenic compound and 17-beta-trenbolone was chosen as an environmental androgenic compound. Although the effects of these model environmental endocrine disruptors are not novel, these chemicals were used essentially as positive controls to represent each of the potential modes of toxicity that could be encountered by future unknown compounds ordered to be run through the LAGDA in support of risk assessment. Endpoints evaluated were larval growth and metamorphic development, blood thyroid hormone, thyroid histopathology, juvenile growth, juvenile histopathology of the liver, gonads, kidneys and reproductive ducts.

This dataset is associated with the following publication: Haselman , J., P. Kosian , J. Korte , A. Olmstead, T. Iguchi, R. Johnson , and S. Degitz. Development of the larval amphibian growth and development assay: Effects of chronic 4-tert-octylphenol or 17ß-trenbolone exposure in Xenopus laevis from embryo to juvenile. JOURNAL OF APPLIED TOXICOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, USA, 36(12): 1639-1650, (2016).