This dataset consists of 1,353 ground observer investigations of mountain lion predation events ("kills") in eastern Nevada, USA, from 2018 to 2022. Over the period of the data collection, we had 29 mountain lions equipped with telemetry collars and we investigated clusters of locations when GPS collar locations were in the same area for three nights -- we used this criteria to identify potential predation events by mountain lions, and then hiked to the GPS cluster location on foot to search for a kill site and to identify the species consumed. Collared mountain lions were both males and females, and species consumed included mule deer, feral horses, bighorn sheep, coyotes, other mountain lions, badgers, beaver, or unknown. On some occasions we hiked to a GPS collar cluster and were not able to find a kill. These data contain those incidents, as well as successful visits in which we identified the species consumed by the collared mountain lion. Note that data are a sample of mountain lion kill sites, not a complete and exhaustive list. Not every cluster was able to be investigated by ground observers, so these data represent a sample of predation events that occurred during the 4-year time period of data collection. Some lions have more predation events than others in the dataset, due to sampling technique.