Soil, soil porewater, groundwater, and playa lake sediment samples were collected between September 2021 and November 2023 at Cannon Air Force Base (CAFB) in eastern New Mexico as part of a study on the sources, fate, and transport of per- and polyfluoroalkyl substances (PFAS). Soil cores (2-foot-long) were collected in September 2021 from six sites that were potential PFAS source areas and one background site. Soil cores were analyzed for targeted PFAS compounds, total oxidizable precursor (TOP) assay, protein content, anions, total organic and inorganic carbon, cation exchange capacity, and pH. Physical properties, which included soil particle size distribution, oxide composition, moisture content, and water potential were also analyzed for the soil samples. Lysimeters were used to obtain interstitial soil porewater samples on two dates. Lysimeter samples were analyzed for PFAS and TOP, and samples with sufficient water volume were sent for wastewater indicator constituents. Groundwater samples were collected from 19 monitoring wells on CAFB in June 2022. Groundwater samples were analyzed for PFAS, TOP, field parameters, major and minor ions, nutrients, dissolved organic carbon, and redox-sensitive species including sulfide, reduced manganese, iron, and methane. Selected samples were analyzed for wastewater indicator constituents. The microbial composition of the soil and groundwater samples are reported in a separate table with sequence counts from the operational taxonomic units (OTU).