The primary data sets consist of continuous water-quality data (temperature, specific conductance, pH, dissolved oxygen, turbidity, nitrate plus nitrite, and streamflow) from in-situ equipment, and discrete water-quality samples (total nitrogen, total phosphorus, suspended sediment concentration, and suspended sediment sieve diameter) collected during site visits at the USGS streamgage School Branch at CR750N at Brownsburg, Indiana, November 17, 2015 to February 6, 2019. The continuous and discrete measurements were used to develop regression models which may be used to compute concentrations and loads of suspended sediment, total nitrogen, and total phosphorus. The secondary data sets consist of daily streamflow, daily turbidity, daily specific conductance, and daily nitrate plus nitrite values collected continuously by in-situ monitors at School Branch at CR750N at Brownsburg, Indiana June 23, 2015 to February 6, 2019 which serve as input explanatory variables for the developed regression models to compute suspended sediment, total nitrogen, and total phosphorus at School Branch at CR750N at Brownsburg. The tertiary data sets for June 23, 2015 to February 6, 2019 are the output data sets that were developed by application of each regression model and include the computed daily mean constituent concentrations (with upper 95-percent prediction interval, and lower 95-percent prediction interval) and daily mean constituent loads (with upper 95-percent prediction interval, and lower 95-percent prediction interval).