A monthly water-balance model (MWBM) is applied to simulate components of the water balance for the period 1950-2100 under ssp245, ssp370, and ssp585 scenarios for the Contiguous United States. The statistically downscaled LOCA2 temperature and precipitation projections from 27 GCMs from the Climate Model Intercomparison Program Phase 6 (CMIP6) are use as input to the water balance model. This data set supports the USGS National Climate Change Viewer (ver. 2). The statistically downscaled data set is: CMIP6-LOCA2: Localized Constructed Analogs (Pierce et al. 2023, bias corrected by a modified version of Livneh et al. 2013) Users interested in the downscaled temperature and precipitation files are referred to the data set home page: LOCA: https://loca.ucsd.edu Bias correction data set: https://cirrus.ucsd.edu/~pierce/nonsplit_precip/ The 27 included GCMs are: ACCESS-CM2, ACCESS-ESM1-5, AWI-CM-1-1-MR, BCC-CSM2-MR, CESM2-LENS, CNRM-CM6-1, CNRM-CM6-1-HR, CNRM-ESM2-1, CanESM5, EC-Earth3, EC-Earth3-Veg, FGOALS-g3, GFDL-CM4, GFDL-ESM4, HadGEM3-GC31-LL, HadGEM3-GC31-MM, INM-CM4-8, INM-CM5-0, IPSL-CM6A-LR, KACE-1-0-G, MIROC6, MPI-ESM1-2-HR, MPI-ESM1-2-LR, MRI-ESM2-0, NorESM2-LM, NorESM2-MM, TaiESM1 There are 72 simulations in total (ssp245=24, ssp370=23, ssp585=25). While the LOCA2 data set supports multiple realizations per model; one MWBM realization per model is provided herein (predominately r1i1p1f1, except when this realization was not available).