The California Groundwater Ambient Monitoring and Assessment Program (GAMA) is a statewide, comprehensive assessment of groundwater quality designed to help better understand and identify risks to groundwater resources. GAMA is being implemented by the California State Water Resources Control Board. The USGS is the technical lead for the Priority Basin Project (PBP), one of the components of the GAMA Program. The initial focus of the GAMA Priority Basin Project in 2004 to 2012 was on assessment of water-quality in groundwater resources used for public drinking water supply (Belitz and others, 2003; 2015). Groundwater basins and sub-basins (472 in total) were prioritized based upon a number of factors (Belitz and others 2003). Two hundred and twenty-seven of these basins and additional areas outside of basins were subsequently grouped into 35 study units comprising 87 Study Areas. The basin and sub-basin boundaries, local geology, local knowledge, and watershed data were used to define the Study Areas. The Study Areas each were divided into equal-area grid cells collectively referred as a "study area grid". The number and size of cells generated for each Study Area was based upon the size of the area being sampled, and the number of public-supply wells available to sample. Three Study Areas contained an insufficient number of public-supply wells for division into a study area grid and were instead directly sampled. The number of cells in a study area grid ranged from 7 to 122 (median 20), and the size of the cells ranged from 4 to 471 km2 (median 25 km2). Additional information about the design of individual study area grids can be found in the reports listed below. The 87 Study Areas are collected and assembled here into one GIS dataset.