The Cores to Disks (C2D) Spitzer Legacy Program used all three Spitzer instruments (IRAC, MIPS, and IRS) to observe sources that span the evolutionary sequence from molecular cores to protoplanetary disks, encompassing a wide range of cloud masses, stellar masses, and star-forming environments. In addition to targeting about 150 known compact cores, it surveyed with IRAC and MIPS (3.6-70 mum) the entire areas of five of the nearest large molecular clouds for new candidate protostars and substellar objects as faint as 0.001 solar luminosities. C2D observed with IRAC and MIPS about 190 systems likely to be in the early stages of planetary system formation (ages up to about 10 Myr), probing the evolution of the circumstellar dust, the raw material for planetary cores.The High Reliability OFF-CLOUD Catalog provides the most reliable list of sources in the C2D OFF-CLOUD fields (ChamaeleonII (CHA_II), Lupus (LUP), Ophiuchus (OPH), Perseus (PER) and Serpens (SER)). It is derived from the Full Catalog but requires good signal-to-noise detection in some bands.