Animals move to locate important resources such as food, water, and mates. Therefore, movement patterns can reflect temporal and spatial availability of resources as well as when, where, and how individuals access such resources. To test these relationships for a predatory reptile, we quantified the effects of prey abundance on the spatial ecology of invasive brown treesnakes (Boiga irregularis). After toxicant-mediated suppression of a brown treesnake population on Guam, we simultaneously used visual encounter surveys to estimate rodent abundance and radiotelemetry to document movement behavior of surviving snakes located in the Habitat Management Unit (HMU) in Northern Guam, Andersen Air Force Base. The impact of prey availability on snake movement is covered under these data via three data files.