Oral sylvatic plague vaccine baits (SPV) and placebo baits were distributed once annually from 2013-2016 on treated and non-treated paired plots from 2013-2016. Black-tailed prairie dogs (BTPD) were live-trapped and permanently marked with passive integrated transponders and ear tags on 4 pairs of plots each year from 2013-2017 to provide capture/recapture data for use in estimating BTPD survival. The first data set (CMR_SPV_RAW_CAPTURE_DATA.csv) lists all captures and associated covariates with each line representing data from a single prairie dog. The second data set (CMR_BTPD_WEIGHTS.csv) lists the weight and associated information for each prairie dog at each handling. The third data set (CMR_FLEAS_BY_HOST.csv) lists the number of fleas collected from each prairie dog at each handling. Funding was provided through the U.S. Fish and Wildlife Service, multiple USGS sources, grants from the Western Association of Fish and Wildlife Agencies, Montana Fish Wildlife and Parks and World Wildlife Fund.