This 50-m-resolution surface presents bathymetric change of South San Francisco Bay, California (hereafter referred to as South Bay). This surface compares a 1-m-resolution digital elevation model (DEM) of the southern portion of San Francisco Bay (Fregoso and others, 2021), comprised of bathymetry data in the South Bay region from the time period referred to as the 2010s because the majority of the surveys were in that decade, to a 50-m-resolution DEM of South Bay comprised of historic surveys from 1979 to 1985 (referred to as the 1980s because the majority of the surveys were in that decade). The creation of this change surface involved the resampling of the 1-m-resolution 2010s DEM to match the 50-m-resolution South Bay DEM. Adjusting the 1990 surface to account for the modern tidal cycle while also applying a bias correction in attempts to account for interpolation uncertainties.