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    • Atomic Model Structure of Intact Monoclonal Antibody Reference Material 8671 (NISTmAb)

    Metadata Updated: July 29, 2022

    As monoclonal antibodies have become a vital resource in medicine, knowledge of their complex molecular structures has increased in importance. Thousands of Fab and Fc fragments are described in the Protein Data Bank. Whole antibodies have been imaged by EM methods and in a few cases, crystallized. The central hinge lacks a unique stable conformation and its dynamic properties are important to antibody function. Monte Carlo and molecular dynamics simulations and small-angle scattering methods have been used to analyze the wide range of configurations that are accessible to antibodies in solution. In order to support the development of antibody-based medicines, the National Institute of Standards and Technology (NIST) has released an extensively characterized IgG1 mAb, called Reference Material 8671 or NISTmAb1. To facilitate modeling of whole antibodies we now report the construction of an all-atom 3-D model of RM 8671. Atomic model structure of the intact monoclonal antibody Reference Material 8671 (NISTmAb), including PDBv3 formatted file containing coordinates for each atom in x, y, z format and the FASTA formatted file containing the primary sequence.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: See this page for license information.

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    Dates

    Metadata Created Date June 12, 2021
    Metadata Updated Date July 29, 2022
    Data Update Frequency irregular

    Metadata Source

    Harvested from NIST

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date June 12, 2021
    Metadata Updated Date July 29, 2022
    Publisher National Institute of Standards and Technology
    Maintainer
    Identifier ark:/88434/mds2-2396
    Data First Published 2021-06-09
    Language en
    Data Last Modified 2021-04-23 00:00:00
    Category Standards:Reference materials, Chemistry:Theoretical chemistry and modeling
    Public Access Level public
    Data Update Frequency irregular
    Bureau Code 006:55
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 36ab20ab-925b-441a-8351-4def21b50bc4
    Harvest Source Id 74e175d9-66b3-4323-ac98-e2a90eeb93c0
    Harvest Source Title NIST
    Homepage URL https://data.nist.gov/od/id/mds2-2396
    License https://www.nist.gov/open/license
    Program Code 006:045
    Source Datajson Identifier True
    Source Hash 8d0f08e0f73b5c01907ca29623fd935c14585a09
    Source Schema Version 1.1

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