The data represent sediment depth profiles of gamma-emitting radionuclides and major, minor, and trace elements in native soil locations around four mineralized sites in Mohave County, Arizona. The four sites represent breccia pipe uranium deposits in the Grand Canyon Region in various lifecycle stages of mining: EZ2 complex (exploration), Arizona 1 mine (standby), Pinenut mine (closed, pre-reclamation), and Kanab North Mine (reclaimed). Gamma spectroscopy determinations were made using high-purity germanium well detectors for analysis of cesium-137 (Cs-137), lead-210 (Pb-210), lead-214 (Pb-214), and bismuth-214 (Bi-214). Major, minor, and trace element determinations were made for using inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma optical emission spectrometry (ICP-OES) for analysis of aluminum (Al), calcium (Ca), iron (Fe), potassium (K), magnesium (Mg), sodium (Na), phosphorus (P), sulfur (S), titanium (Ti), silver (Ag), arsenic (As), barium (Ba), beryllium (Be), bismuth (Bi), cadmium (Cd), cerium (Ce), cobalt (Co), chromium (Cr), cesium (Cs), copper (Cu), gallium (Ga), hafnium (Hf), indium (In), lanthanum (La), lithium (Li), lutetium (Lu), manganese (Mn), molybdenum (Mo), niobium (Nb), nickel (Ni), lead (Pb), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), tin (Sn), strontium (Sr), tantalum (Ta), terbium (Tb), tellurium (Te), thorium (Th), thallium (Tl), uranium (U), vanadium (V), tungsten (W), yttrium (Y), ytterbium (Yb), zinc (Zn), and zirconium (Zr). The data were collected to assess the potential of fallout radionuclides (Cs-137 and unsupported Pb-210) to help understand the distribution of subsurface contaminants related to mining activity. The Pb-210, Pb-214, and Bi-214 data can be used to calculate Ra-226 and unsupported Pb-210.