Association between adverse cardiovascular outcomes and PM2.5 data obtained from monitors, CMAQ models, and satellite models.

Metadata Updated: January 7, 2019

Background: Adverse cardiovascular events have been linked with PM2.5 exposure obtained primarily from air quality monitors, which rarely co-locate with participant residences. Modeled PM2.5 predictions at finer resolution may more accurately predict residential exposure; however few studies have compared results across different exposure assessment methods. Methods: We utilized a cohort of 5679 patients who had undergone a cardiac catheterization between 2002–2009 and resided in NC. Exposure to PM2.5 for the year prior to catheterization was estimated using data from air quality monitors (AQS), Community Multiscale Air Quality (CMAQ) fused models at the census tract and 12 km spatial resolutions, and satellite-based models at 10 km and 1 km resolutions. Case status was either a coronary artery disease (CAD) index>23 or a recent myocardial infarction (MI). Logistic regression was used to model odds of having CAD or an MI with each 1-unit (μg/m3) increase in PM2.5, adjusting for sex, race, smoking status, socioeconomic status, and urban/rural status. Results: We found that the elevated odds for CAD>23 and MI were nearly equivalent for all exposure assessment methods. One difference was that data from AQS and the census tract CMAQ showed a rural/urban difference in relative risk, which was not apparent with the satellite or 12 km-CMAQ models. Conclusions: Long-term air pollution exposure was associated with coronary artery disease for both modeled and monitored data. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: Clinical data are located in: C:UsersrdevlinOneDrive - Environmental Protection Agency (EPA)Excel FilesCathgen

Satellite data are located in : C:UsersrdevlinOneDrive - Environmental Protection Agency (EPA)Excel FilesNew Ikm Satellite Data C:UsersrdevlinOneDrive - Environmental Protection Agency (EPA)Excel FilesSatellite Data CMAQ data are located in C:UsersrdevlinOneDrive - Environmental Protection Agency (EPA)Excel FilesCMAQ Data. Format: There are two types of datasets used in this study: clinical data taken from patient records at the Duke Medical Center; and air pollution data (PM2.5) taken from a federal reference monitor located in Raleigh, CMAQ data obtained from collaborators at Georgia Tech and NERL/ORD, and satellite data obtained from collaborators at Harvard.

Metadata are in the form of Excel spreadsheets that contain columns of data that specify clinical and exposure information for each individual participating in the study.

This dataset is associated with the following publication: McGuinn, L., C. Ward-Caviness, A. Schneider, Q. Di, A. Chudnovsky, J. Schwartz, P. Koutrakis, A. Russell, V. Garcia, W. Krause, E. Hauser, L. Neas, W. Cascio, D. Diaz-Sanchez, and R. Devlin. Fine Particulate Matter and Cardiovascular Disease: Comparison of Assessment Methods for Long-term Exposure. ENVIRONMENTAL RESEARCH. Academic Press Incorporated, Orlando, FL, USA, 159: 16-23, (2017).

Access & Use Information

Restricted: This dataset can only be accessed or used under certain conditions. License: See this page for license information.
EPA Category: Personally Identifiable Information (PII), NARA Category: Privacy

Downloads & Resources

No file downloads have been provided. The publisher may provide downloads in the future or they may be available from their other links.



Metadata Created Date August 25, 2017
Metadata Updated Date January 7, 2019

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date August 25, 2017
Metadata Updated Date January 7, 2019
Publisher U.S. EPA Office of Research and Development (ORD)
Unique Identifier
Robert Devlin
Maintainer Email
Public Access Level restricted public
Bureau Code 020:00
Schema Version
Harvest Object Id 315f2879-f7fc-4e3d-b20b-fb6df37b394b
Harvest Source Id cf9b0004-f9fd-420e-bade-a86839e82acf
Harvest Source Title EPA ScienceHub
Data Last Modified 2016-12-01
Program Code 020:094
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Rights EPA Category: Personally Identifiable Information (PII), NARA Category: Privacy
Source Datajson Identifier True
Source Hash 49fb4f26c0164c15fbb58086b785298257b726ad
Source Schema Version 1.1

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