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Assessing the Impact of Wastewater Treatment Plant Effluent on Downstream Drinking Water-Source Quality Using a Zebrafish (Danio Rerio) Liver Cell-Based Metabolomics Approach

Metadata Updated: November 12, 2020

The datafile presents the data used to create the figures in the manuscript. These include: a) Two-component score plots of hydrophilic and lipophilic ZFL cell extracts analyzed with NMR and GC-MS, respectively; b) The t-test filtered difference spectra (exposed minus control) generated from binned 1H NMR spectra (0.5–5.0 ppm in chemical shift) of hydrophilic extracts of ZFL cells; c) Bar chart showing the fold change of 21 annotated metabolites from the lipophilic extracts that exhibited different normalized abundance at one or more of the six sites relative to the control as measured by GC-MS; d) The summed intensity values for significantly changed metabolites from the t-test filtered difference spectra for both hydrophilic and lipophilic extracts across six sampling sites; and e) Relative normalized abundances for metabolites identified in the cholesterol and fatty acid synthesis pathways from lipophilic ZFL extracts.

This dataset is associated with the following publication: Zhen, H., D. Ekman, T. Collette, S. Glassmeyer, M. Mills, E. Furlong, D. Kolpin, and Q. Teng. Assessing the impact of wastewater treatment plant effluent on downstream drinking water-source quality using a zebrafish (Danio Rerio) liver cell-based metabolomics approach. WATER RESEARCH. Elsevier Science Ltd, New York, NY, USA, 145: 198-209, (2018).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2018-09-13
Public Access Level public
Bureau Code 020:00
Schema Version
Data Dictionary
Data Dictionary Type application/vnd.openxmlformats-officedocument.wordprocessingml.document
Harvest Object Id a48690f7-4f57-4b1d-b696-58fb81bc3eed
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:096
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents
Source Datajson Identifier True
Source Hash dbef2d619dfbdf9f64118101a5d2c7c90083cd30
Source Schema Version 1.1

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