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    • Assessing cell line models for species differences in 6PPD-quinone sensitivity

    Metadata Updated: October 29, 2025

    Coho salmon have been shown to be highly sensitive to the tire transformation chemical 6PPD-quinone, with concentrations contained in stormwater sufficient to induce mortality in up to 90% of the entire fall coho run. Other salmonid species (chinook, sockeye, chum) are much less sensitive to 6PPD-quinone induced mortality. This data examines the varying species sensitivities across salmoids using in vivo exposures in juvenile fish. We then used established cell lines forom these species to assess their suitability for in vitro studies concerning species differences in toxicokinetics using fluorescence and absorbance-based plate assays.

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date September 12, 2025
    Metadata Updated Date October 29, 2025

    Metadata Source

    Harvested from DOI USGS DCAT-US

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date September 12, 2025
    Metadata Updated Date October 29, 2025
    Publisher U.S. Geological Survey
    Maintainer
    Identifier http://datainventory.doi.gov/id/dataset/usgs-6442af79d34ee8d4ade8cc86
    Data Last Modified 2023-07-24T00:00:00Z
    Category geospatial
    Public Access Level public
    Bureau Code 010:12
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://ddi.doi.gov/usgs-data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 4797836b-0560-47bd-b245-15b2679135db
    Harvest Source Id 2b80d118-ab3a-48ba-bd93-996bbacefac2
    Harvest Source Title DOI USGS DCAT-US
    Metadata Type geospatial
    Old Spatial -124.7600, 45.5400, -116.9100, 49.0000
    Source Datajson Identifier True
    Source Hash 8f02978a45541f27256f0a52d08b3e4f0847fa6dc9d7ec196a4b8ae7db99e11f
    Source Schema Version 1.1
    Spatial {"type": "Polygon", "coordinates": -124.7600, 45.5400, -124.7600, 49.0000, -116.9100, 49.0000, -116.9100, 45.5400, -124.7600, 45.5400}

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