These data were collected to evaluate if arrowweed (Pluchea sericea) individuals and genotypes collected from across a 5.3 degree Celsius temperature gradient and grown in a common greenhouse environment had different physiological and morphological responses to inundation. The objectives of the study were to assess if 1) individuals from climatically different provenances differ in their morphological and physiological phenotypes, 2) individuals from climatically different provenances differ in their response to inundation, and 3) phenotypes and inundation responses are partially controlled by genotype. These data represent measurements made on 248 plants that were grown in a greenhouse and, also in a greenhouse subjected to different inundation depths for three months. These data were collected at Northern Arizona University in the Research Greenhouse complex, a laboratory in the Biology Building, or the Genetics Core Facility in Flagstaff, AZ. Greenhouse measurements were made in June-September 2019. Laboratory and genetics data were collected between Sept 2019 and April 2021. These data were collected by the USGS Grand Canyon Monitoring and Research Center and Northern Arizona University and represent a combination of direct plant measurements and simple sequence repeat (SSR, microsatellite) genetic data. These data can be used to compare the individual plant growth and phenotypes, examine response to inundation in Pluchea sericea, get trait estimates for P. sericea in a well-watered environment, and estimate the contribution of genotype to plant phenotype and environmental response.