This data release contains inputs for and outputs from hydrologic simulations for the conterminous United States (CONUS) using the Precipitation Runoff Modeling System (PRMS) version 5.2.1 and the USGS National Hydrologic Model infrastructure (NHM, Regan and others, 2018). These simulations were developed to provide estimates of the water budget for the period 1979 to 2021 for one pre-calibration and three calibration configurations: 1) calibration by hydrologic response unit (byHRU), 2) calibration by select headwaters (byHW), and 3) calibration by select headwaters with streamflow observations (byHWobs). The three versions of model parameters and associated model output included in this data release are described in Hay and others (2023). Specific file types include: 1) input atmospheric forcings of minimum air temperature, maximum air temperature, and daily precipitation accumulation derived from a gridded observation-based dataset developed by Abatzoglou (2013), 2) input parameter files, 3) output files of simulated water budget components for each hydrologic response unit and stream segment, and 4) performance statistics at selected streamgage locations. The first three years of the simulations are considered 'model initialization' and should not be included in any subsequent analysis.