This data release provides digital flight line data for a high-resolution airborne magnetic and radiometric survey over Columbia, South Carolina, and the surrounding region. The airborne data collection was funded by the U.S. Geological Survey (USGS) Earth Mapping Resource Initiative (Earth MRI) with goals of better understanding placer deposits containing critical mineral resources titanium, zirconium, and rare earth elements and of imaging the crystalline basement partly buried beneath Atlantic Coastal Plain sediments. The survey was flown northwest of and slightly overlapping an airborne magnetic and radiometric survey collected in 2019 (Shah, 2020). The northwestern boundary of the 2020 survey lies within the metamorphic and igneous rocks of the Piedmont Province. Together, the 2019 and 2020 airborne surveys provide a transect across Atlantic Coastal Plain sediments from the Piedmont Province to the Atlantic Ocean. References cited: Shah, A.K., 2020, Airborne magnetic and radiometric survey, Charleston, South Carolina and surrounds, 2019: U.S. Geological Survey data release, https://doi.org/10.5066/P9EWQ08L.