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Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific

Published by U.S. EPA Office of Research and Development (ORD) | U.S. Environmental Protection Agency | Catalog Last Checked: August 03, 2026 at 12:49 AM | Dataset Last Updated: February 01, 2023
The dataset is comprised of multiple data-frames. Our focus is on sex and brain region specific responses to ozone in a rat model. The PCR data describes the gene expression from listed brain regions resulting from ozone exposure. Complex enzymes were also assayed due to their sensitivity to oxidative stress using biochemical colorimetric assays. And finally, we collected data for oxidative stress artifacts such as protein carbonyl productions, total antioxidants, and enzyme activity. This dataset is associated with the following publication: Valdez, M., D. Freeborn, P. Vulimiri, J. Valdez, U. Kodavanti, and P. Kodavanti. Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific.. International Journal of Molecular Sciences. MDPI, Basel, SWITZERLAND, 24(7): 1, (2023).

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Complete Metadata
@type dcat:Dataset
accessLevel public
bureauCode 
[
  "020:00"
]
contactPoint 
{
  "fn": "Prasada Kodavanti",
  "hasEmail": "mailto:kodavanti.prasada@epa.gov"
}
describedBy https://pasteur.epa.gov/uploads/10.23719/1528538/documents/datadictionary_MFO3.xlsx
describedByType application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
description The dataset is comprised of multiple data-frames. Our focus is on sex and brain region specific responses to ozone in a rat model. The PCR data describes the gene expression from listed brain regions resulting from ozone exposure. Complex enzymes were also assayed due to their sensitivity to oxidative stress using biochemical colorimetric assays. And finally, we collected data for oxidative stress artifacts such as protein carbonyl productions, total antioxidants, and enzyme activity. This dataset is associated with the following publication: Valdez, M., D. Freeborn, P. Vulimiri, J. Valdez, U. Kodavanti, and P. Kodavanti. Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific.. International Journal of Molecular Sciences. MDPI, Basel, SWITZERLAND, 24(7): 1, (2023).
distribution 
[
  {
    "title": "Gene Symbol Table.docx",
    "mediaType": "application/vnd.openxmlformats-officedocument.wordprocessingml.document",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/Gene%20Symbol%20Table.docx"
  },
  {
    "title": "PCRsummary.csv",
    "mediaType": "text/plain",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/PCRsummary.csv"
  },
  {
    "title": "carbonylData.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/carbonylData.csv"
  },
  {
    "title": "com1_dataframe.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/com1_dataframe.csv"
  },
  {
    "title": "com2_dataframe.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/com2_dataframe.csv"
  },
  {
    "title": "com4_dataframe.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/com4_dataframe.csv"
  },
  {
    "title": "rosData_2.csv",
    "mediaType": "text/csv",
    "downloadURL": "https://pasteur.epa.gov/uploads/10.23719/1528538/rosData_2.csv"
  }
]
identifier https://doi.org/10.23719/1528538
keyword 
[
  "air pollution",
  "brain",
  "gender",
  "gene expression"
]
license https://pasteur.epa.gov/license/sciencehub-license.html
modified 2023-02-01
programCode 
[
  "020:000"
]
publisher 
{
  "name": "U.S. EPA Office of Research and Development (ORD)",
  "subOrganizationOf": {
    "name": "U.S. Environmental Protection Agency",
    "subOrganizationOf": {
      "name": "U.S. Government"
    }
  }
}
references 
[
  "https://doi.org/10.3390/ijms24076404",
  "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094823"
]
rights 
null
title Acute Ozone-Induced Transcriptional Changes in Markers of Oxidative Stress and Glucocorticoid Signaling in the Rat Hippocampus and Hypothalamus are Sex-Specific

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