A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type
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A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells
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Complete Metadata
| @type | dcat:Dataset |
|---|---|
| accessLevel | public |
| accrualPeriodicity | irregular |
| bureauCode |
[ "026:00" ] |
| contactPoint |
{ "fn": "GeneLab Outreach", "@type": "vcard:Contact", "hasEmail": "mailto:genelab-outreach@lists.nasa.gov" } |
| description | Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the cultured TK6 lymphoblastoid cells upon exposure to micro-gravity conditions. The results reported here indicate that simulated microgravity alters methylation patterns in a limited way and subsequently the expression of genes involved in stress response like ATF3 FBXO17 MAP3K13 and VCL in TK6 cells. Overall design: Examination of RNA-seq with 2 replicates each for 1 cell type |
| distribution |
[ { "@type": "dcat:Distribution", "title": "A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells", "format": "HTML", "mediaType": "text/html", "description": "GeneLab Study Page", "downloadURL": "https://genelab-data.ndc.nasa.gov/genelab/accession/GLDS-91" } ] |
| identifier | nasa_genelab_GLDS-91_43bs-bf56 |
| issued | 2021-05-21 |
| keyword |
[ "data-processing", "data-transformation", "genelab-rnaseq-data-processing-protocol", "growth-protocol", "library-construction", "microgravity-simulation", "nucleic-acid-extraction", "nucleic-acid-sequencing", "treatment-protocol" ] |
| landingPage | https://data.nasa.gov/dataset/a-study-of-gene-expression-influenced-by-simulated-microgravity-in-human-lymphoblastoid-ce |
| license | http://www.usa.gov/publicdomain/label/1.0/ |
| modified | 2025-04-23 |
| programCode |
[ "026:005" ] |
| publisher |
{ "name": "National Aeronautics and Space Administration", "@type": "org:Organization" } |
| theme |
[ "Earth Science" ] |
| title | A study of gene expression influenced by simulated microgravity in human lymphoblastoid cells |
