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A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in Early Life Stages of Zebrafish (Danio rerio)

Metadata Updated: July 30, 2021

Our findings identified five structural categories of PFAS prone to metabolism. The metabolism pathways of PFAS are highly related to their structures and significantly impact their bioaccumulations and toxicities. We also verified CES1 as an enzyme capable of hydrolyzing diverse PFAS, with strong substrate preferences towards perfluoroalkyl amides. This dataset is not publicly accessible because: Data generated by external academic lab with chemicals provided by EPA under an MTA. EPA’s contribution was providing the PFAS library. It can be accessed through the following means: Contact the corresponding author Hui Peng, Mailing address: Department of Chemistry, University of Toronto, Toronto, Ontario, M5S3H6, Canada. E-mail address: hui.peng@utoronto.ca. Format: Not available.

This dataset is associated with the following publication: Han, J., W. Gu, H. Barrett, D. Yang, S. Tang, J. Sun, J. Liu, H. Krause, K. Houck, and H. Peng. A Roadmap to the Structure-Related Metabolism Pathways of Per- and Polyfluoroalkyl Substances in the Early Life Stages of Zebrafish (Danio rerio). ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 129(7): 077004, (2021).

Access & Use Information

Public: This dataset is intended for public access and use. License: See this page for license information.

Downloads & Resources

No file downloads have been provided. The publisher may provide downloads in the future or they may be available from their other links.

References

https://doi.org/10.1289/ehp7169

Dates

Metadata Created Date July 30, 2021
Metadata Updated Date July 30, 2021

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date July 30, 2021
Metadata Updated Date July 30, 2021
Publisher U.S. EPA Office of Research and Development (ORD)
Maintainer
Identifier https://doi.org/10.23719/1518708
Data Last Modified 2020-03-31
Public Access Level public
Bureau Code 020:00
Schema Version https://project-open-data.cio.gov/v1.1/schema
Harvest Object Id 5349c757-32f9-417e-8643-afd19642613b
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
License https://pasteur.epa.gov/license/sciencehub-license-non-epa-generated.html
Program Code 020:095
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Related Documents https://doi.org/10.1289/ehp7169
Source Datajson Identifier True
Source Hash 254c1d9c843f48ba78e8c5451bb56db7c813ea51
Source Schema Version 1.1

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