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Metadata Updated: November 12, 2020

Laboratories and vivariums are maintained at ambient temperatures (Ta) of 20-24 ⁰C and it is widely accepted that mice maintained under these conditions are cold stressed. When mice are inactive and sleeping in the daytime, their zone of thermoneutrality associated with a basal metabolic rate is 30-32 ⁰C. If given a choice, mice will use thermoregulatory behavior to seek out thermoneutral temperatures during the daytime. The cold stress of a vivarium can be problematic to researchers requiring an animal model that is not stressed metabolically. However, it may not be practical or economically feasible to maintain an animal vivarium at thermoneutral temperatures. One problem with raising the Ta of a vivarium is that personnel wearing protective equipment will be subject to considerable heat stress. In this paper, we present plans for the construction and operation of a device that allows mice to utilize a refuge with a heated floor maintained at an approximate thermoneutral temperatures (30-32 ⁰C). The device is made of inexpensive, readily available materials and utilizes a disposable hand warmer (HotHands®) as a heat source. One hand warmer provides a thermoneutral environment for approximately 12 hours. This device is easily adapted to a standard mouse or rat cage and requires brief maintenance each day to change the heating pad. With this device in a standard cage, mice can select an environment associated with thermoneutral conditions during the daytime when inactive and sleeping. At night, the mice are more active, have a higher metabolic rate, and prefer cooler Ta’s. Egress from the warmed plate allows mice to seek cooler Ta’s at night.

This dataset is associated with the following publication: Gordon, C., E. Puckett, E. Repasky, and A. Johnstone. A DEVICE THAT ALLOWS RODENTS TO BEHAVIORALLY THERMOREGULATE WHEN HOUSED IN VIVARIUMS. COMPARATIVE MEDICINE. American Association for Laboratory Animal Science, Memphis, TN, USA, 173-176, (2017).

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Public: This dataset is intended for public access and use. License: See this page for license information.

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Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020

Metadata Source

Harvested from EPA ScienceHub

Additional Metadata

Resource Type Dataset
Metadata Created Date November 12, 2020
Metadata Updated Date November 12, 2020
Publisher U.S. EPA Office of Research and Development (ORD)
Data Last Modified 2016-11-08
Public Access Level public
Bureau Code 020:00
Schema Version
Harvest Object Id 431bc65a-bb04-45e9-a8e8-6b75d0cbc45c
Harvest Source Id 04b59eaf-ae53-4066-93db-80f2ed0df446
Harvest Source Title EPA ScienceHub
Program Code 020:094
Publisher Hierarchy U.S. Government > U.S. Environmental Protection Agency > U.S. EPA Office of Research and Development (ORD)
Source Datajson Identifier True
Source Hash c39b97955474de5877606b8bd99a6d9955c87219
Source Schema Version 1.1

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