6 datasets found
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Federal
A surrogate-based approach for post-genomic partner identification
U.S. Department of Health & Human Services —
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present... -
Federal
The SWIRM domain: a conserved module found in chromosomal proteins points to novel chromatin-modifying activities
U.S. Department of Health & Human Services —
Using computational sequence-profile analysis methods, a previously uncharacterized, predicted α-helical domain of about 85 residues was identified in chromosomal... -
Federal
Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor
U.S. Department of Health & Human Services —
Background The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many... -
Federal
Development of an optimized interaction-mating protocol for large-scale yeast two-hybrid analyses
U.S. Department of Health & Human Services —
Background Protein-protein interactions have decisive roles in almost all aspects of the structural and functional organization of cells. But in spite of the... -
Federal
Interaction of neuronal nitric oxide synthase with alpha
U.S. Department of Health & Human Services —
Background The C-terminal four amino acids (GEEV) of human α1A-adrenergic receptors (ARs) have been reported to interact with the PDZ domain of neuronal nitric oxide... -
Federal
Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p
U.S. Department of Health & Human Services —
Background SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind...
6 datasets found