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Federal
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells
U.S. Department of Health & Human Services —
Background Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked... -
Federal
Socio-demographic factors and self-reported funtional status: the significance of social support
U.S. Department of Health & Human Services —
Background The aim of the present work was to investigate the relative importance of socio-demographic and physical health status factors for subjective functioning,... -
Federal
Androgen and retinoic acid interaction in LNCaP cells, effects on cell proliferation and expression of retinoic acid receptors and epidermal growth factor receptor
U.S. Department of Health & Human Services —
Background Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might... -
Federal
An assessment of the usefulness of a rapid immuno-chromatographic test, "Determine™ malaria pf" in evaluation of intervention measures in forest villages of central India
U.S. Department of Health & Human Services —
Background Plasmodium falciparum malaria, is a major health problem in forested tribal belt of central India. Rapid and accurate methods are needed for the diagnosis... -
Federal
Advantages of larval control for African malaria vectors: Low mobility and behavioural responsiveness of immature mosquito stages allow high effective coverage
U.S. Department of Health & Human Services —
Background Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult... -
Federal
Alveolar epithelial type II cell: defender of the alveolus revisited
U.S. Department of Health & Human Services —
In 1977, Mason and Williams developed the concept of the alveolar epithelial type II (AE2) cell as a defender of the alveolus. It is well known that AE2 cells... -
Federal
Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and
U.S. Department of Health & Human Services —
Background SP100 is a nuclear protein that displays a number of alternative splice variants. In Old World monkeys, apes and humans one of these variants is extended... -
Federal
Detection and characterization of the
U.S. Department of Health & Human Services —
Background Virulence genes on Salmonella pathogenicity island 1 (SPI1) are coordinately regulated by HilA, a member of the OmpR/ToxR family of transcription factors.... -
Federal
TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
U.S. Department of Health & Human Services —
Background MAdCAM-1 is an adhesion molecule expressed in Peyer's patches and lymphoid tissues which is mobilized by cytokines like TNF-α and is a major determinant of... -
Federal
Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays
U.S. Department of Health & Human Services —
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both... -
Federal
Interkingdom gene fusions
U.S. Department of Health & Human Services —
Background: Genome comparisons have revealed major lateral gene transfer between the three primary kingdoms of life - Bacteria, Archaea, and Eukarya. Another... -
Federal
A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of
U.S. Department of Health & Human Services —
Background: Non-long terminal repeat (non-LTR) retrotransposons are eukaryotic mobile genetic elements that transpose by reverse transcription of an RNA intermediate.... -
Federal
The regulation of CD5 expression in murine T cells
U.S. Department of Health & Human Services —
Background CD5 is a pan-T cell surface marker that is also present on a subset of B cells, B-1a cells.Functional and developmental subsets of T cells express... -
Federal
Cytosolic acidification as a signal mediating hyperosmotic stress responses in
U.S. Department of Health & Human Services —
Background Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of... -
Federal
Genomic comparisons among
U.S. Department of Health & Human Services —
Background Insertion Sequence (IS) elements are mobile genetic elements widely distributed among bacteria. Their activities cause mutations, promoting genetic... -
Federal
Doxycycline-induced expression of sense and inverted-repeat constructs modulates
U.S. Department of Health & Human Services —
Background A tetracycline-regulated (conditional) system for RNA interference (RNAi) would have many practical applications. Such a strategy was developed using RNAi... -
Federal
Mobilization of seed storage lipid by Arabidopsis seedlings is retarded in the presence of exogenous sugars
U.S. Department of Health & Human Services —
Background Soluble sugar levels must be closely regulated in germinating seeds to ensure an adequate supply of energy and building materials for the developing...