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Federal
Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers
U.S. Department of Health & Human Services —
Background Previously, we have demonstrated a marked inhibition of codeine glucuronidation by diclofenac in human liver tissue homogenate. We therefore aimed to... -
Federal
A comparative study of gallstones from children and adults using FTIR spectroscopy and fluorescence microscopy
U.S. Department of Health & Human Services —
Background Cholelithiasis is the gallstone disease (GSD) where stones are formed in the gallbladder. The main function of the gallbladder is to concentrate bile by... -
Federal
Chronic obstructive pulmonary disease, asthma and protective effects of food intake: from hypothesis to evidence?
U.S. Department of Health & Human Services —
Evidence for a role of diet in asthma and chronic obstructive pulmonary disease (COPD) has been accumulating rapidly over the past decade. Associations have been... -
Federal
New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy products
U.S. Department of Health & Human Services —
Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium... -
Federal
Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
U.S. Department of Health & Human Services —
Objective To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.... -
Federal
Organ culture: a new model for vascular endothelium dysfunction
U.S. Department of Health & Human Services —
Background Endothelium dysfunction is believed to play a role in the development of cardiovascular disease. The aim of the present study was to evaluate the... -
Federal
Design of a trial evaluating myocardial cell protection with cariporide, an inhibitor of the transmembrane sodium-hydrogen exchanger: the Guard During Ischemia Against Necrosis (GUARDIAN) trial
U.S. Department of Health & Human Services —
Inhibition of the sodium-hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt... -
Federal
NF-κB DNA-binding activity in embryos responding to a teratogen, cyclophosphamide
U.S. Department of Health & Human Services —
Background The Rel/NF-κB transcription factors have been shown to regulate apoptosis in different cell types, acting as inducers or blockers in a stimuli- and cell... -
Federal
Ileal mucosal bile acid absorption is increased in Cftr knockout mice
U.S. Department of Health & Human Services —
Background Excessive loss of bile acids in stool has been reported in patients with cystic fibrosis. Some data suggest that a defect in mucosal bile acid transport... -
Federal
Differential modulation of cellular death and survival pathways by conjugated bile acids
U.S. Department of Health & Human Services —
Background The liver-derived McNtcp.24 cells transport bile acids and show distinctive responses to the two classes of conjugated bile acids. Whereas taurine-... -
Federal
Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice
U.S. Department of Health & Human Services —
Background The intrarenal natriuretic hormone dopamine (DA) is metabolised by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). Inhibition of COMT, as... -
Federal
The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it
U.S. Department of Health & Human Services —
Background Experimental colitis with features similar to inflammatory bowel disease (IBD) has initially been described. A detailed analysis of inflammatory cells has... -
Federal
Inability of Serotonin to Activate the c-Jun N-terminal Kinase and p38 Kinase Pathways in Rat Aortic Vascular Smooth Muscle Cells
U.S. Department of Health & Human Services —
Background Serotonin (5-HT, 5-hydroxytryptamine) activates the Extracellular Signal-Regulated Kinase (ERK)/ Mitogen-Activated Protein Kinase (MAPK) pathways, in... -
Federal
Arterial Wall Properties and Womersley Flow in Fabry Disease
U.S. Department of Health & Human Services —
Background Fabry disease is an X-linked recessive lysosomal storage disease resulting in the cellular accumulation of globotriaosylceramide particularly... -
Federal
Prehospital point of care testing of blood gases and electrolytes — an evaluation of IRMA
U.S. Department of Health & Human Services —
Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A... -
Federal
Omapatrilat normalizes renal function curve in spontaneously hypertensive rats
U.S. Department of Health & Human Services —
Background The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats... -
Federal
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia
U.S. Department of Health & Human Services —
Background Manipulation of total homocysteine concentration with oral methionine is associated with impairment of endothelial-dependent vasodilation. This may be... -
Federal
Effects of EDTA and Sodium Citrate on hormone measurements by fluorometric (FIA) and immunofluorometric (IFMA) methods
U.S. Department of Health & Human Services —
Background Measurements of hormonal concentrations by immunoassays using fluorescent tracer substance (Eu3+) are susceptible to the action of chemical agents that may... -
Federal
Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line.
U.S. Department of Health & Human Services —
Background Aquaporin-1 (AQP1) channels are constitutively active water channels that allow rapid transmembrane osmotic water flux, and also serve as cyclic-GMP-gated... -
Federal
Hamster oocyte membrane potential and ion permeability vary with preantral cumulus cell attachment and developmental stage
U.S. Department of Health & Human Services —
Background In vitro maturation of mammalian oocytes is an area of great interest due to its potential application in the treatment of infertility. The morphological...