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Federal
Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports
U.S. Department of Health & Human Services —
Background This investigation was undertaken to describe patient perception and awareness of the polycystic ovary syndrome (PCOS), the most common cause of... -
Federal
Antinociceptive and anti-inflammatory effects of
U.S. Department of Health & Human Services —
Background Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-... -
Federal
Functional interaction between TRP4 and CFTR in mouse aorta endothelial cells
U.S. Department of Health & Human Services —
Background This study describes the functional interaction between the putative Ca2+ channel TRP4 and the cystic fibrosis transmembrane conductance regulator, CFTR,... -
Federal
A transcriptional response to Wnt protein in human embryonic carcinoma cells
U.S. Department of Health & Human Services —
Background Wnt signaling is implicated in many developmental decisions, including stem cell control, as well as in cancer. There are relatively few target genes known... -
Federal
Pacing in congestive heart failure
U.S. Department of Health & Human Services —
Despite the major advances in medical drug therapy, heart failure remains a syndrome associated with high mortality and morbidity. Biventricular or left ventricular... -
Federal
Gender-related plasma levels of progesterone, interleukin-8 and interleukin-10 during and after cardiopulmonary bypass in infants and children
U.S. Department of Health & Human Services —
Background It is known that proinflammatory and anti-inflammatory cytokines are released during and after cardiopulmonary bypass (CPB) in infants and children. Sex... -
Federal
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg
U.S. Department of Health & Human Services —
In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have... -
Federal
Humoral immune response to an allogenic foetus in normal fertile women and recurrent aborters
U.S. Department of Health & Human Services —
Background Several humoral immune factors are responsible for a successful pregnancy. There are a few studies, which demonstrate the role of antipaternal cytotoxic... -
Federal
Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma
U.S. Department of Health & Human Services —
Background Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has... -
Federal
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K
U.S. Department of Health & Human Services —
Background The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using... -
Federal
Disruption of spinal cord white matter and sciatic nerve geometry inhibits axonal growth
U.S. Department of Health & Human Services —
Background Axons within the mature mammalian central nervous system fail to regenerate following injury, usually resulting in long-lasting motor and sensory deficits.... -
Federal
Transforming growth factor-β1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
U.S. Department of Health & Human Services —
Background Functional antagonism between transforming growth factor beta (TGF-β) and hyaluronidase has been demonstrated. For example, testicular hyaluronidase PH-20... -
Federal
Cell-cell interactions in synovitis: Antigen presenting cells and T cell interaction in rheumatoid arthritis
U.S. Department of Health & Human Services —
The synovial tissue in rheumatoid arthritis (RA) patients is enriched with mature antigen presenting cells (APCs) and many T lymphocytes. Interactions between APCs... -
Federal
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
U.S. Department of Health & Human Services —
Background The most important receptor for nitic oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative... -
Federal
LDL-cholesterol lowering effect of a generic product of simvastatin compared to simvastatin (Zocor™) in Thai hypercholesterolemic subjects – a randomized crossover study, the first report from Thailand
U.S. Department of Health & Human Services —
Background It is commonly agreed that people with a high blood LDL-cholesterol will have a higher risk of coronary artery disease (CAD) than people with low blood... -
Federal
Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies
U.S. Department of Health & Human Services —
Human tumour necrosis factor (TNF)-like weak inducer of apoptosis (hTWEAK) and two anti-hTWEAK mAbs were tested for their ability to elicit or block inflammatory... -
Federal
Anti-cytokine therapy in chronic destructive arthritis
U.S. Department of Health & Human Services —
Tumor necrosis factor (TNF) and interleukin-1 (IL-1) are considered to be master cytokines in chronic, destructive arthritis. Therapeutic approaches in rheumatoid... -
Federal
Superantigen antagonist peptides
U.S. Department of Health & Human Services —
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-... -
Federal
Bone loss: Factors that regulate osteoclast differentiation - an update
U.S. Department of Health & Human Services —
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among... -
Federal
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
U.S. Department of Health & Human Services —
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo...