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Federal
Immediate Transcriptional Changes in Response to High Dose Radiation Exposure recent views
National Aeronautics and Space Administration —
One of the most likely risks astronauts on long duration space missions face is exposure to ionizing radiation associated with highly energetic and charged heavy... -
Federal
Real-time quantitative PCR analysis of human cardiovascular progenitor cells flown aboard the International Space Station recent views
National Aeronautics and Space Administration —
Adult and neonatal human cardiovacular progenitor cell clonal populations were flown aboard the ISS for 12 days prior to fixation in RNAprotect. Gene expression... -
Federal
Candida albicans response to spaceflight (NASA STS-115) recent views
National Aeronautics and Space Administration —
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen Candida albicans grown... -
Federal
Gravitational signature of synchronized cell cultures in particular cell cycle stages recent views
National Aeronautics and Space Administration —
Cell cycle and cell proliferation are decoupled under altered gravity conditions. We have previously shown that semisolid cell cultures of Arabidopsis suffer overall... -
Federal
Proteomics and Transcriptomics analysis of Arabidopsis Seedlings in Microgravity recent views
National Aeronautics and Space Administration —
On Earth plants are constantly exposed to a gravitational field of 1G. Gravity affects a plant in every step of its development. Germinating seedlings orient their... -
Federal
Evaluation of in vitro macrophage differentiation during space flight recent views
National Aeronautics and Space Administration —
We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle... -
Federal
A study of alterations DNA epigenetic modifiincations (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells recent views
National Aeronautics and Space Administration —
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the... -
Federal
Transcription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1 recent views
National Aeronautics and Space Administration —
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis but it can switch to a tumor promoter during neoplastic... -
Federal
Dynamic gene expression response to altered gravity in human T cells (parabolic flight) recent views
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
The development of Drosophila melanogaster during space flight recent views
National Aeronautics and Space Administration —
In prospective human exploration of outer space the need to maintain a species over several generations under changed gravity conditions may arise. This paper reports... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day recent views
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special... -
Federal
Gamma radiation and HZE treatment of seedlings in Arabidopsis recent views
National Aeronautics and Space Administration —
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the... -
Federal
HSFA2 functions in the physiological adaptation of undifferentiated plant cells to spaceflight microgravity environment recent views
National Aeronautics and Space Administration —
The Heat Shock Factor A2 (HsfA2) as a part of the HSF network is essential to the plant s response to almost any environmental stress and to the cellular homeostatic... -
Federal
Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland recent views
National Aeronautics and Space Administration —
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body xce xb3 radiation and mammary glands were surgically removed 2-month after radiation.... -
Federal
Transcription profiling of human MCF10A cells subjected to ionizing radiation and treatment with transforming growth factor beta-1 recent views
National Aeronautics and Space Administration —
Transforming growth factor beta-1 (TGFbeta) is a tumor suppressor during the initial stage of tumorigenesis but it can switch to a tumor promoter during neoplastic... -
Federal
Chronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts recent views
National Aeronautics and Space Administration —
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate... -
Federal
Dynamic gene expression response to altered gravity in human T cells (parabolic flight) recent views
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Expression profiling of soleus muscle under the effect of simulated spaceflight recent views
National Aeronautics and Space Administration —
Spaceflight imposes the risk of skeletal muscle atrophy for astronauts. The understanding of muscle atrophy because of spaceflight is limited but continued efforts... -
Federal
Effect of electromagnetic fields on the chondrogenic differentiation under microgravity conditions recent views
National Aeronautics and Space Administration —
A combination therapy of electromagnetic fields (EMF) and simulated microgravity (SMG) has not been examined in regenerative medicine of cartilage. In the present... -
Federal
Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study recent views
National Aeronautics and Space Administration —
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent...