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Federal
Global gene expression profiling of radiation-induced rat mammary carcinomas
National Aeronautics and Space Administration —
To investigate gene expression patterns in rat mammary carcinomas induced by ionizing radiation. Gene expression patterns were analyzed in radiation-induced rat... -
Federal
Characterization of Epigenetic Regulation in an Extraterrestrial Environment: The Arabidopsis Spaceflight Methylome [Bisulfite-seq]
National Aeronautics and Space Administration —
When germinated and grown on-board the ISS (International Space Station) plant do not exhibit abnormal structures but they do have altered growth habits and this... -
Federal
Murine TCR-beta repertoire sequencing
National Aeronautics and Space Administration —
The purpose of this project was to determine the effects of chronic exposure to unpredictable mild socio-environmental stressors during gestation on the TCR-beta... -
Federal
Dissecting transcriptional responses of nucleolin mutants to red light stimulation and darkness in ground reference conditions
National Aeronautics and Space Administration —
Understanding plant adaptive responses to the space environment is a requisite for enabling space farming. Spaceflight produce deleterious effects on plant cells... -
Federal
Arg1 functions in the physiological adaptation of undifferentiated plant cells to spaceflight
National Aeronautics and Space Administration —
In this study transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity-1 (Arg1) a gene known to affect... -
Federal
Effects of spaceflight on murine skeletal muscle gene expression
National Aeronautics and Space Administration —
Spaceflight results in a number of adaptations to skeletal muscle including atrophy and shifts towards faster muscle fiber types. To identify changes in gene... -
Federal
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU) microgravity in mice: brain transcriptomic and epigenomic data
National Aeronautics and Space Administration —
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose... -
Federal
Gamma radiation and HZE treatment of seedlings in Arabidopsis
National Aeronautics and Space Administration —
Plants exhibit a robust transcriptional response to gamma radiation which includes the induction of transcripts required for homologous recombination and the... -
Federal
Transcription profiling of mouse osteoblasts under static vs simulated microgravity
National Aeronautics and Space Administration —
The total RNA was extracted from 2T3 pre-osteoblast cells exposed to static or simulated microgravity (Rotating Wall Vessel) conditions. The RNA was then sent to... -
Federal
Gene expression response to simulated gravity and hypergravity in human T cells
National Aeronautics and Space Administration —
We investigated differentially regulated and stably expressed genes in human Jurkat T lymphocytic cells in 5min simulated microgravity and hypergravity and compared... -
Federal
Response of the EPI-200 human 3-D skin model to high and low doses of protons
National Aeronautics and Space Administration —
Accumulating data suggest that the biological responses to high and low doses of radiation are qualitatively different necessitating the direct study of low dose... -
Federal
Drosophila melanogaster gene expression changes after spaceflight.
National Aeronautics and Space Administration —
Gene expression levels were determined in 3rd instar and adult Drosophila melanogaster reared during spaceflight to elucidate the genetic and molecular mechanisms... -
Federal
Arg1 functions in the physiological adaptation of undifferentiated plant cells to spaceflight
National Aeronautics and Space Administration —
In this study transcriptome profiling was used to gain insight into the spaceflight adaptation role of Altered response to gravity-1 (Arg1) a gene known to affect... -
Federal
Dissecting Low Atmospheric Pressure Stress: Transcriptome Responses to the Components of Hypobaria in Arabidopsis [Experiment 2]
National Aeronautics and Space Administration —
Controlled hypobaria presents biology with an environment that is never encountered in terrestrial ecology yet the apparent components of hypobaria are stresses... -
Federal
Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
National Aeronautics and Space Administration —
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data... -
Federal
Environmental and facility conditions promote singular gravity responses of transcriptome during Drosophila metamorphosis
National Aeronautics and Space Administration —
Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene... -
Federal
Transcriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen
National Aeronautics and Space Administration —
This study describes the transcriptional response of P. aeruginosa PAO1 to low-Earth orbit environmental conditions. Our aim was to assess whether the microgravity... -
Federal
Eruca sativa Rocket Science RNA-seq
National Aeronautics and Space Administration —
In the Rocket Science citizen science project Eruca sativa (salad rocket) seeds stored for six months on board of the International Space Station caused delayed crop... -
Federal
Proton irradiation augments the reduction in tumor progression observed with advanced age
National Aeronautics and Space Administration —
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have... -
Federal
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity
National Aeronautics and Space Administration —
Physical forces greatly influence the growth and function of an organism. Altered gravity can perturb normal development and induce corresponding changes in gene...