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Federal
Beverage specific alcohol intake in a population-based study: Evidence for a positive association between pulmonary function and wine intake
U.S. Department of Health & Human Services —
Background Lung function is a strong predictor of cardiovascular and all-cause mortality. Previous studies suggest that alcohol exposure may be linked to impaired... -
Federal
Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis
U.S. Department of Health & Human Services —
Purpose A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) .... -
Federal
A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues
U.S. Department of Health & Human Services —
Background Proximal chromosome 15q is implicated in neurodevelopmental disorders including Prader-Willi and Angelman syndromes, autistic disorder and developmental... -
Federal
Evolution of gene fusions: horizontal transfer versus independent events
U.S. Department of Health & Human Services —
Background Gene fusions can be used as tools for functional prediction and also as evolutionary markers. Fused genes often show a scattered phyletic distribution,... -
Federal
Atrial fibrillation in a primary care practice: prevalence and management
U.S. Department of Health & Human Services —
Background Atrial fibrillation is a common serious cardiac arrhythmia. Knowing the prevalence of atrial fibrillation and documentation of medical management are... -
Federal
A surrogate-based approach for post-genomic partner identification
U.S. Department of Health & Human Services —
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present... -
Federal
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder
U.S. Department of Health & Human Services —
Background Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-... -
Federal
Influence of twenty-five per cent human serum albumin on total and ionized calcium concentrations
U.S. Department of Health & Human Services —
Background: A inverse correlation has been found between changes in ionized calcium concentrations and the addition of albumin in vitro, which may explain adverse... -
Federal
Prescribing patterns in premenstrual syndrome
U.S. Department of Health & Human Services —
Background Over 300 therapies have been proposed for premenstrual syndrome. To date there has been only one survey conducted in the UK of PMS treatments prescribed by... -
Federal
The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients
U.S. Department of Health & Human Services —
Objective To estimate the mortality and length of stay in the intensive care unit (ICU) attributable to clinically important gastrointestinal bleeding in mechanically... -
Federal
Alarms in the intensive care unit: how can the number of false alarms be reduced?
U.S. Department of Health & Human Services —
Many alarms, as they now exist in most monitoring systems, are not usually perceived as helpful by the medical staff because of the high incidence of false alarms.... -
Federal
The methionine salvage pathway in
U.S. Department of Health & Human Services —
Background Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very... -
Federal
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
U.S. Department of Health & Human Services —
Background Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations... -
Federal
B lymphocyte involvement in ankylosing spondylitis: the heavy chain variable segment gene repertoire of B lymphocytes from germinal center-like foci in the synovial membrane indicates antigen selection
U.S. Department of Health & Human Services —
The synovial membrane (SM) of affected joints in ankylosing spondylitis (AS) is infiltrated by germinal center-like aggregates (foci) of lymphocytes similar to... -
Federal
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
U.S. Department of Health & Human Services —
Background This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the... -
Federal
Experience collecting interim data on mortality: an example from the RALES study
U.S. Department of Health & Human Services —
Introduction The Randomized Aldactone Evaluation Study (RALES) randomized 822 patients to receive 25 mg spironolactone daily and 841 to receive placebo. The primary... -
Federal
Chromosomal mapping, gene structure and characterization of the human and murine
U.S. Department of Health & Human Services —
Background Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in... -
Federal
Do we need clinical trials to test the ability of transdermal HRT to prevent coronary heart disease?
U.S. Department of Health & Human Services —
Postmenopausal hormone replacement therapy (HRT) with oral oestrogen was predicted to reduce coronary heart disease (CHD) risk by 50%. Randomized controlled trials... -
Federal
Mutant loxP vectors for selectable marker recycle and conditional knock-outs
U.S. Department of Health & Human Services —
Background Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40... -
Federal
Computational discovery of sense-antisense transcription in the human and mouse genomes
U.S. Department of Health & Human Services —
Overlapping but oppositely oriented transcripts have the potential to form sense-antisense perfect double-stranded (ds) RNA duplexes. A bioinformatics approach has...